AQP1

Gene Symbol AQP1
Entrez Gene 358
Alt Symbol AQP-CHIP, CHIP28, CO
Species Human
Gene Type protein-coding
Description aquaporin 1 (Colton blood group)
Other Description aquaporin 1 (channel-forming integral protein, 28kDa, CO blood group)|aquaporin-1|aquaporin-CHIP|channel-like integral membrane protein, 28-kDa|urine water channel|water channel protein for red blood cells and kidney proximal tubule
Swissprots Q8TDC1 F5GY19 B5BU39 E9PC21 Q8TBI5 E7EM69 P29972
Accessions AAC16481 AAC23788 AAL87136 AAX24129 CAC84072 CAQ51480 CBG76070 EAL24446 EAW93971 EAW93972 P29972 AB451275 BAG70089 AB451402 BAG70216 AK298091 BAG60376 AK298313 BAG60567 AK300995 BAG62614 AK301351 BAG62897 AK304684 BAG65455 AK309608 AK309688 AK309691 AK312656 BAG35539 AU122128 AY312580 AAR16185 AY312581 AAR16186 BC022486 AAH22486 BC141905 BI837828 DA197236 DA712111 DQ892366 ABM83292 DQ895575 ABM86501 M77829 AAA58425 S73482 AAB31193 U41517 AAC50648 U41518 AAC50649 NM_001185060 NP_001171989 NM_001185061 NP_001171990 NM_001185062 NP_001171991 NM_198098 NP_932766 NM_000385
Function Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. {ECO:0000269|PubMed:1373524}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:23219802}; Multi-pass membrane protein {ECO:0000269|PubMed:23219802}.
Tissue Specificity Detected in erythrocytes (at protein level). Expressed in a number of tissues including erythrocytes, renal tubules, retinal pigment epithelium, heart, lung, skeletal muscle, kidney and pancreas. Weakly expressed in brain, placenta and liver. {ECO:0000269|PubMed:23219802}.
Top Pathways Proximal tubule bicarbonate reclamation, Bile secretion