COL3A1

Gene Symbol COL3A1
Entrez Gene 1281
Alt Symbol EDS4A
Species Human
Gene Type protein-coding
Description collagen, type III, alpha 1
Other Description Ehlers-Danlos syndrome type IV, autosomal dominant|alpha1 (III) collagen|collagen alpha-1(III) chain|collagen, fetal
Swissprots Q541P8 Q7KZ56 Q9UC91 Q6LDJ2 Q15112 P02461 Q9UC90 Q6LDB3 Q16403 Q6LDJ3 D2JYH5 D3DPH4 P78429 Q9UC89 V9GZI1 R4N3C5 Q8N6U4 Q9UC88 Q53S91
Accessions AAA51999 AAA52000 AAA52001 AAA52002 AAA52040 AAA52041 AAD13937 AAL13167 AAY24164 ACZ58371 AGL34959 CDM55397 CDM55578 EAX10909 EAX10910 EAX10911 P02461 AI755052 AK091853 AK308010 BC028178 AAH28178 BP374999 M11134 AAA52004 M13146 AAA52003 M59227 AAB59383 S79877 AAB35615 X01655 CAA25821 X01742 CAA25878 X06700 CAA29886 X07240 CAA30229 X14420 CAA32583 X15332 CAA33387 NM_000090 NP_000081
Function Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of GPR56 in the developing brain and binding to GPR56 inhibits neuronal migration and activates the RhoA pathway by coupling GPR56 to GNA13 and possibly GNA12.
Subcellular Location Secreted, extracellular space, extracellular matrix {ECO:0000255|PROSITE-ProRule:PRU00793}.
Top Pathways Focal adhesion, ECM-receptor interaction, Amoebiasis, Protein digestion and absorption, PI3K-Akt signaling pathway