trim33

Gene Symbol trim33
Entrez Gene 733198
Alt Symbol ecto, ptc7, rfg7, tf1g, tif1g, tif1gamma, tifgamma
Species Xenopus
Gene Type protein-coding
Description tripartite motif containing 33
Other Description E3 ubiquitin-protein ligase TRIM33|TIF1-gamma|ectodermin|transcription intermediary factor 1-gamma|tripartite motif-containing 33|tripartite motif-containing protein 33
Swissprots Q56R14
Accessions Q56R14 AY781409 AAX10105 BC170291 AAI70291 BC170319 AAI70319 NM_001095608 NP_001089077
Function Acts as an E3 ubiquitin-protein ligase for smad4. Promotes ectoderm embryonic development at the expense of other germ layers. Inhibits mesodermal differentiation. Promotes neural development of the ectoderm. Promotes smad4 alpha degradation via the ubiquitin proteasome pathway. May act as a transcriptional repressor (By similarity). {ECO:0000250}.
Subcellular Location Nucleus {ECO:0000269|PubMed:15820681}.