| Gene Symbol | CD28 |
|---|---|
| Entrez Gene | 940 |
| Alt Symbol | Tp44 |
| Species | Human |
| Gene Type | protein-coding |
| Description | CD28 molecule |
| Other Description | CD28 antigen|T-cell-specific surface glycoprotein CD28 |
| Swissprots | Q13964 Q8NI56 Q70WG0 P10747 Q8WXJ2 Q8NI55 A8KAC1 Q8NI54 Q52M23 Q9BYV0 |
| Accessions | AAA51944 AAA51945 AAL40931 AAY24123 ABK41938 EAW70347 EAW70348 EAW70349 EAW70350 EAW70351 P10747 AA311148 AF222341 AAF33792 AF222342 AAF33793 AF222343 AAF33794 AJ295273 CAC29237 AJ517504 CAD57003 AK292986 BAF85675 AK303421 BAG64473 AK313313 BAG36118 AW241446 BC093698 AAH93698 BC112085 AAI12086 BF509568 DA939711 J02988 AAA60581 XM_006712862 XP_006712925 XM_011512194 XP_011510496 XM_011512195 XP_011510497 XM_011512196 XP_011510498 XM_011512197 XP_011510499 NM_001243077 NP_001230006 NM_001243078 NP_001230007 NM_006139 NP_006130 |
| Function | Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. |
| Subcellular Location | Membrane; Single-pass type I membrane protein. |
| Tissue Specificity | Expressed in T-cells and plasma cells, but not in less mature B-cells. |
| Top Pathways | T cell receptor signaling pathway, Type I diabetes mellitus, Graft-versus-host disease, Allograft rejection, Intestinal immune network for IgA production |