| Gene Symbol | MAPK12 |
|---|---|
| Entrez Gene | 6300 |
| Alt Symbol | ERK-6, ERK3, ERK6, MAPK 12, P38GAMMA, PRKM12, SAPK-3, SAPK3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | mitogen-activated protein kinase 12 |
| Other Description | MAP kinase 12|MAP kinase p38 gamma|extracellular signal-regulated kinase 6|mitogen-activated protein kinase 3|mitogen-activated protein kinase p38 gamma|stress-activated protein kinase 3 |
| Swissprots | Q6IC53 P53778 Q99588 Q14260 Q99672 |
| Accessions | EAW73521 EAW73522 P53778 AK098058 BAG53571 AK123665 BAG53932 AK289770 BAF82459 AK294422 BAH11760 AK307421 AK307724 AK308768 BC015741 AAH15741 BX640648 CAE45794 CB123561 CR456515 CAG30401 CU013115 CAK54546 CU013403 CAK54845 DQ892787 ABM83713 DQ896034 ABM87033 U66243 AAB40118 X79483 CAA55984 Y10487 CAA71511 NM_001303252 NP_001290181 NM_002969 NP_002960 |
| Function | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in myoblast differentiation and also in the down-regulation of cyclin D1 in response to hypoxia in adrenal cells suggesting MAPK12 may inhibit cell proliferation while promoting differentiation. Phosphorylates DLG1. Following osmotic shock, MAPK12 in the cell nucleus increases its association with nuclear DLG1, |
| Subcellular Location | Cytoplasm. Nucleus. Mitochondrion. Note=Mitochondrial when associated with SH3BP5. In skeletal muscle colocalizes with SNTA1 at the neuromuscular junction and throughout the sarcolemma (By similarity). {ECO:0000250}. |
| Tissue Specificity | Highly expressed in skeletal muscle and heart. {ECO:0000269|PubMed:11991731, ECO:0000269|PubMed:8633070}. |
| Top Pathways | Proteoglycans in cancer, Retrograde endocannabinoid signaling, Sphingolipid signaling pathway, Rap1 signaling pathway, Epstein-Barr virus infection |