MEC3

Gene Symbol MEC3
Entrez Gene 850995
Alt Symbol PIP3, PSO9
Species Yeast
Gene Type protein-coding
Description Mec3p
Other Description -
Swissprots Q05887 P87260 Q02574 D6VYT4
Accessions DAA09600 Q02574 NM_001182176 NP_013391
Function Component of the checkpoint clamp complex involved in the surveillance mechanism that allows the DNA repair pathways to act to restore the integrity of the DNA prior to DNA synthesis or separation of the replicated chromosomes. Associates with sites of DNA damage and modulates the MEC1 signaling pathway and the activation of RAD53 in response to DNA damage at phase G1. The complex also physically regulates DNA polymerase zeta-dependent mutagenesis by controlling the access of polymerase zeta to damaged DNA. {ECO:0000269|PubMed:12271137, ECO:0000269|PubMed:12604797, ECO:0000269|PubMed:12672803, ECO:0000269|PubMed:16137930, ECO:0000269|PubMed:16169844, ECO:0000269|PubMed:16202664, ECO:0000269|PubMed:9891048, ECO:0000269|PubMed:9988274}.
Subcellular Location Nucleus {ECO:0000305}.
Top Pathways Cell cycle - yeast, Meiosis - yeast