| Gene Symbol | ncbp2 |
|---|---|
| Entrez Gene | 8625983 |
| Alt Symbol | DDBDRAFT_0218899, DDBDRAFT_0233456, DDB_0218899, DDB_0233456 |
| Species | Dictyostelium discoideum |
| Gene Type | protein-coding |
| Description | RNA recognition motif-containing protein RRM |
| Other Description | RNA-binding region RNP-1 domain-containing protein|nuclear cap-binding protein subunit 2 |
| Swissprots | Q54KR9 |
| Accessions | EAL63873 XM_632269 XP_637361 |
| Function | Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing and RNA-mediated gene silencing (RNAi). The CBC complex is involved in miRNA-mediated RNA interference and is required for primary microRNAs (miRNAs) processing. In the CBC complex, ncbp2 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires ncbp1 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure (By similarity). {ECO:0000250}. |
| Subcellular Location | Nucleus {ECO:0000250}. |
| Top Pathways | Spliceosome, RNA transport, mRNA surveillance pathway |