| Gene Symbol | GALNT4 |
|---|---|
| Entrez Gene | 8693 |
| Alt Symbol | GALNAC-T4, GALNACT4 |
| Species | Human |
| Gene Type | protein-coding |
| Description | polypeptide N-acetylgalactosaminyltransferase 4 |
| Other Description | UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 4|UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 4 (GalNAc-T4)|polypeptide GalNAc transferase 4|pp-GaNTase 4|protein-UDP acetylgalactosaminyltransferase 4 |
| Swissprots | O00208 Q8N4A0 B4DMX6 B2R775 |
| Accessions | CAA69875 EAW97428 Q8N4A0 AK026150 AK026438 AK312870 BAG35722 AW835269 BC036390 AAH36390 CR739813 DA109687 DQ891684 ABM82610 DQ894869 ABM85795 DQ896831 ABM87830 EU176606 ABW03407 NM_003774 NP_003765 |
| Function | Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threonine residue on the protein receptor. Has a highest activity toward Muc7, EA2 and Muc2, with a lowest activity than GALNT2. Glycosylates 'Thr-57' of SELPLG. |
| Subcellular Location | Golgi apparatus membrane {ECO:0000305|PubMed:9804815}; Single-pass type II membrane protein {ECO:0000305|PubMed:9804815}. |
| Tissue Specificity | Ubiquitous. Highly expressed in mucous cells. {ECO:0000269|PubMed:9804815}. |
| Top Pathways | Mucin type O-Glycan biosynthesis |