Huwentoxin-IV inhibits NaV1.7 channels heterologously expressed in Xenopus oocytes. A. Time course of current inhibition by 500 nM Huwentoxin-IV (ab141873) (green). Currents were elicited by a voltage ramp between -80 mV to +20 mV (60 ms) every 10 seconds from holding potential of -80 mV. B. Example traces of current response to voltage ramp application before (black) and during (green) 500 nM Huwentoxin-IV application.

Huwentoxin-IV inhibits NaV1.7 channels heterologously expressed in Xenopus oocytes. A. Time course of current inhibition by 500 nM Huwentoxin-IV (ab141873) (green). Currents were elicited by a voltage ramp between -80 mV to +20 mV (60 ms) every 10 seconds from holding potential of -80 mV. B. Example traces of current response to voltage ramp application before (black) and during (green) 500 nM Huwentoxin-IV application.


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