NS-1619 blocks KCa1.1 currents in Xenopus oocytes. A. Families of KCa1.1 channel current responses to increasing voltage step stimulation (from -50 mV to + 50 mV), before (left) and during (right) application of 100 µM NS-1619 (ab141824). Currents were elicited by 100 ms voltage step from -100mV applied every 10 sec. B. Time course of current amplitude at 0 mV before, during application of 100 µM NS-1619 (green) and upon wash, demonstrating the current amplitude enhancement. C. Voltage dependence of KCa1.1 channel activity enhancement.

NS-1619 blocks KCa1.1 currents in Xenopus oocytes. A. Families of KCa1.1 channel current responses to increasing voltage step stimulation (from -50 mV to + 50 mV), before (left) and during (right) application of 100 µM NS-1619 (ab141824). Currents were elicited by 100 ms voltage step from -100mV applied every 10 sec. B. Time course of current amplitude at 0 mV before, during application of 100 µM NS-1619 (green) and upon wash, demonstrating the current amplitude enhancement. C. Voltage dependence of KCa1.1 channel activity enhancement.


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