Ryanodine inhibits the elevation of intracellular Ca2+ by PI(3,5)P2 in primary cardiac myocytes. Top figure shows fura-2 ratiometric changes in intracellular Ca2+ in an isolated ventricular adult cardiac myocyte after treatment with PI(3,5)P2, ultimately resulting in contraction. Bottom figure shows that ryanodine inhibited the release of SR Ca2+ to both caffeine and PI(3,5)P2.

Ryanodine inhibits the elevation of intracellular Ca2+ by PI(3,5)P2 in primary cardiac myocytes. Top figure shows fura-2 ratiometric changes in intracellular Ca2+ in an isolated ventricular adult cardiac myocyte after treatment with PI(3,5)P2, ultimately resulting in contraction. Bottom figure shows that ryanodine inhibited the release of SR Ca2+ to both caffeine and PI(3,5)P2.


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