APETx2 blocks inward currents of ASIC3 channels expressed in Xenopus oocytes. Membrane potential was held at 5 mV and whole cell current was continuously recorded. ASIC3 currents were elicited by rapid exposure to pH 5 in physiological solution every 20 sec. 1 µM APETx2 (ab141849) was introduced into the bath via perfusion, resulting in a reversible inhibition of the pH dependent inward transients.

APETx2 blocks inward currents of ASIC3 channels expressed in Xenopus oocytes. Membrane potential was held at 5 mV and whole cell current was continuously recorded. ASIC3 currents were elicited by rapid exposure to pH 5 in physiological solution every 20 sec. 1 µM APETx2 (ab141849) was introduced into the bath via perfusion, resulting in a reversible inhibition of the pH dependent inward transients.


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