Anti-EGFR immunotoxin D2C7 (scFv)-Gel

• Supplier: Creative Biolabs
• Catalog: AGTO-G018G
• Applications: Cytotoxic Assay FA
• Species Reactivities: Human
• SwissProt/Accession: P00533
• Gene: EGFR
• Description: This immunotoxin was achieved by conjugating/fusing the Anti-EGFR scFv to gelonin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to tumor cells. Once bind, the toxin enters cells by receptor-mediated endocytosis. Then, gelonin, like abrin and ricin, inhibits protein synthesis by damaging the 60S subunit of mammalian ribosomes. It was designed for inhibiting tumor growth.