Anti-EGFR immunotoxin D2C7 (IgG)-DT

Name Anti-EGFR immunotoxin D2C7 (IgG)-DT
Supplier Creative Biolabs
Catalog AGTO-G019D
Applications Cytotoxic Assay FA
Species Reactivities Human
SwissProt/Accession P00533
Gene EGFR
Description This immunotoxin was achieved by conjugating/fusing the Anti-EGFR monoclonal antibody to Diphtheria toxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to tumor cells and the toxin enters cells by receptor-mediated endocytosis. Before the N-terminal 193 amino acids corresponding to the catalytic domain of DT enzyme, -II binding and elongation factor into the eukaryotic cell, the cell can catalyze specific elongation factor EF2 amide His699 of diphtheria ADP2 ribosylation occurs, thereby preventing protein synthesis and causes cell death. It was designed for treatment of brain tumors.
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