| Name | Mouse GDNF |
|---|---|
| Supplier | ABBIOTEC |
| Catalog | 600362 |
| Category | Protein |
| Prices | $250.00 |
| Sizes | 10 µg |
| Species Reactivities | Mouse |
| Nature | Recombinant |
| Source | E. coli. Endotoxin level as measured by LAL is <0.05ng/ug or <0.5EU/ug. |
| Purity | Purity > 95% as determined by RP-HPLC and reducing and non-reducing SDS-PAGE. Protein Content determined by UV spectroscopy at 280 nm and analysis by RP-HPLC calibrated against a known standard. Quantitation on SDS-PAGE against a known standard. |
| Bioactivity | The activity is determined by the dose-dependent proliferation of C6 cells and is typically less than 1 ug/mL. Specific activity: 1 x 10e3 units/mg |
| Gene | Gdnf |
| Sequence | MSPDKQAAL PRRENRNRQAA AASPENSRGK GRRGQRGKNR GCVLTAIHLN VTDLGLGYET KEELIFRYCS GSCESAETMY DKILKNLSRS RRLTSDKVGQ ACCRPVAFDD DLSFLDDNLV YHILRKHSAK RCGCI |
| Description | Glial Cell Line-Derived Neurotrophic Factor, or GDNF, is a neurotrophic factor that is closely related to other neurotrophic factors such as Neurturin, Persephin, and Artemin, by a common structural feature called the cysteine-knot. GDNF signals through a multicomponent system of receptors that includes receptors known as RET, and GFRalpha 1-4 to promote dopamine uptake, survival and differentiation of neurons. Mouse GDNF is produced in E.coli. Recombinant mouse GDNF is a non-glycosylated homodimer, containing two 135 amino acid chains, with a total molecular weight of 30.2 kDa. |
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