| Description |
VIP peptides cause vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach, and gall bladder. The vasoactive intestinal peptide (VIP) is a 28-aa long peptide corresponding to aa45-72 of the guinea pig VIP precursor after cleavage. VIP is a neuropeptide synthesized in the central nervous system, which enhances the formation of adenosine 3'-5'-cyclic monophosphate in cerebral cortex and hypothalamus. VIP also modulates the cholinergic as well as serotonergic neurotransmitter systems.
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