Recombinant Mouse Cathepsin L Protein, CF

• Supplier: R&D Systems
• Catalog: 1515-CY
• Category: Protein
• Prices: $329.00
• Sizes: 10 µg
• Species Reactivities: Mouse
• Nature: Recombinant
• Source: Mouse myeloma cell line, NS0-derived Thr18-Asn334, with a C-terminal 10-His tag
• Purity: >95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• Bioactivity: Measured by its ability to cleave the fluorogenic peptide substrate Z-LR-AMC (Catalog # ES008). The specific activity is >5,000 pmol/min/µg, as measured under the described conditions. See Activity Assay Protocol on www.RnDSystems.com.
• Endotoxin: <1.0 EU per 1 μg of the protein by the LAL method.
• SwissProt/Accession: P06797
• Gene: Ctsl
• Sequence: Thr18

Product References

Cathepsins limit macrophage necroptosis through cleavage of Rip1 kinase. - Cathepsins limit macrophage necroptosis through cleavage of Rip1 kinase.

McComb S, Shutinoski B, Thurston S, Cessford E, Kumar K, Sad S. J Immunol. 2014 Jun 15;192(12):5671-8.

The cystatin M/E-cathepsin L balance is essential for tissue homeostasis in - The cystatin M/E-cathepsin L balance is essential for tissue homeostasis in

Zeeuwen PL, van Vlijmen-Willems IM, Cheng T, Rodijk-Olthuis D, Hitomi K, Hara-Nishimura I, John S, Smyth N, Reinheckel T, Hendriks WJ, Schalkwijk J. FASEB J. 2010 Oct;24(10):3744-55.

Cathepsin L proteolytically processes histone H3 during mouse embryonic stem cell - Cathepsin L proteolytically processes histone H3 during mouse embryonic stem cell

Duncan EM, Muratore-Schroeder TL, Cook RG, Garcia BA, Shabanowitz J, Hunt DF, Allis CD. Cell. 2008 Oct 17;135(2):284-94.