Recombinant Mouse TNF RI/TNFRSF1A Fc Chimera Protein, CF

• Supplier: R&D Systems
• Catalog: 430-RI/CF
• Category: Protein
• Prices: $329.00
• Sizes: 50 µg
• Species Reactivities: Mouse
• Nature: Recombinant
• Source: Mouse myeloma cell line, NS0-derived Mouse TNF RI (Leu30-Ala212) Accession # P25118 DIEGRMD Human IgG 1 (Pro100-Lys330) 6-His tag N-terminus C-terminus
• Purity: >90%, by SDS-PAGE under reducing conditions and visualized by silver stain
• Bioactivity: Measured by its ability to inhibit the TNF-alpha mediated cytotoxicity in the L‑929 mouse fibroblast cells in the presence of the metabolic inhibitor actinomycin D. Matthews, N. and M.L. Neale (1987) in Lymphokines and Interferons, A Practical Approach. Clemens, M.J. et al . (eds): IRL Press. 221. The ED 50 for this effect is 0.5-2.0 ng/mL in the presence of 0.1 ng/mL recombinant mouse TNF-alpha.
• Endotoxin: <0.10 EU per 1 μg of the protein by the LAL method.
• SwissProt/Accession: P25118
• Gene: Tnfrsf1a
• Sequence: Leu30

Product References

Comparative Biochemical and Functional Analysis of Viral and Human Secreted Tumor - Comparative Biochemical and Functional Analysis of Viral and Human Secreted Tumor

Pontejo SM, Alejo A, Alcami A. J Biol Chem. 2015 Jun 26;290(26):15973-84.

Pharmacokinetic and Pharmacodynamic Characterisation of an Anti-Mouse TNF - Pharmacokinetic and Pharmacodynamic Characterisation of an Anti-Mouse TNF

Goodall LJ, Ovecka M, Rycroft D, Friel SL, Sanderson A, Mistry P, Davies ML, Stoop AA. PLoS One. 2015 Sep 9;10(9):e0137065.

TNFR2 interposes the proliferative and NF-kappaB-mediated inflammatory response - TNFR2 interposes the proliferative and NF-kappaB-mediated inflammatory response

Bruggeman LA, Drawz PE, Kahoud N, Lin K, Barisoni L, Nelson PJ. Lab Invest. 2011 Mar;91(3):413-25.