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BLM Antibody (BFL103): sc-13584
- BLM Antibody (BFL103) is a mouse monoclonal IgG1 κ, cited in 3 publications, provided at 200 µg/ml
- raised against full length BLM (Bloom's Syndrome Protein) of human origin
- recommended for detection of BLM of human origin by WB, IF and ELISA
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for BLM Antibody (BFL103) for WB applications. These reagents are now offered in bundles with BLM Antibody (BFL103) (see ordering information below).
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SEE ALSO...
Bloom′s syndrome is an autosomal recessive disorder characterized by pre- and post-natal growth deficiencies, sun sensitivity, immunodeficiency and a predisposition to various cancers. The gene responsible for Bloom′s syndrome, BLM, encodes a protein homologous to the RecQ helicase of E. coli and is mutated in most Bloom′s syndrome patients. One characteristic of Bloom′s syndrome is an increased frequency of sister chromatid exchange (SCE). BLM has been shown to unwind G4 DNA, and a failure of this function is thought to be responsible for the increased rate of SCE. BLM is known to be translocated to the nucleus, where its ATPase activity is stimulated by both single- and double-stranded DNA. Mutations in the yeast SGS1, a homolog of BLM, are known to cause mitotic hyperrecombination similiar to that observed in Bloom′s cells.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BLM Antibody (BFL103) | sc-13584 | 200 µg/ml | $310.00 | |||
BLM Antibody (BFL103): m-IgG Fc BP-HRP Bundle | sc-538897 | 200 µg Ab; 10 µg BP | $348.00 | |||
BLM Antibody (BFL103): m-IgG1 BP-HRP Bundle | sc-541130 | 200 µg Ab; 20 µg BP | $348.00 |