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TCF-4 Antibody (H-7): sc-271287
- TCF-4 Antibody (H-7) is a mouse monoclonal IgG3 κ, cited in 3 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 565-592 at the C-terminus of TCF-4 of human origin
- recommended for detection of TCF-4 of mouse, rat and human origin by WB, IP, IF and ELISA
- TransCruz reagent for ChIP application (sc-271287 X, 200 µg/0.1 ml)
- See TCF-4 (D-4): sc-166699 for TCF-4 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG3 BP-HRP is the preferred secondary detection reagent for TCF-4 Antibody (H-7) for WB applications. This reagent is now offered in a bundle with TCF-4 Antibody (H-7) (see ordering information below).
T cell factors (TCFs) comprise a family of DNA-binding transcriptional activators that are essential for lymphoid cell development. These transcription factors are activated by the Wnt-1 and Wingless pathways and are characterized by the presence of a conserved protein motif, the high mobility group (HMG) 1 box, which mediates DNA binding. TCF-4 mainly localizes in the cytoplasm and is transported into the nucleus directly bound to β-catenin in a cooperative manner. This TCF-4/β-catenin complex induces expression of Wnt target genes, including multiple cancer-associated genes. c-Jun also interacts with TCF-4 and β-catenin, and the phosphorylation-dependent interaction between c-Jun and TCF4 regulates intestinal tumorigenesis by integrating JNK and APC/β-catenin. TCF-4 is also implicated in bipolar affective disorder.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TCF-4 Antibody (H-7) | sc-271287 | 200 µg/ml | $310.00 | |||
TCF-4 Antibody (H-7): m-IgG3 BP-HRP Bundle | sc-550401 | 200 µg Ab; 40 µg BP | $348.00 | |||
TCF-4 (H-7) Neutralizing Peptide | sc-271287 P | 100 µg/0.5 ml | $67.00 | |||
TCF-4 Antibody (H-7) X | sc-271287 X | 200 µg/0.1 ml | $310.00 |