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GSK-3α Antibody (9D5G1): sc-81166
- GSK-3α Antibody (9D5G1) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against a recombinant protein corresponding to amino acids 84-150 of GSK-3α of human origin
- recommended for detection of GSK-3α of mouse, rat and human origin by WB and IP
- See GSK-3α/β (0011-A): sc-7291 for GSK-3α antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for GSK-3α Antibody (9D5G1). This work is in progress.
Glycogen synthase kinase 3, or GSK-3, is a serine/threonine, proline-directed kinase involved in a diverse array of signaling pathways, including glycogen synthesis and cellular adhesion, and has been implicated in Alzheimer′s disease. Two forms of GSK-3, designated GSK-3α and GSK-3β, have been identified and differ in their subcellular localization. Tau, a microtubule-binding protein which serves to stabilize microtubules in growing axons, is found to be hyper-phosphorylated in paired helical filaments (PHF), the major fibrous component of neurofibrillary lesions associated with Alzheimer′s disease. Hyper- phosphorylation of Tau is thought to be the critical event leading to the assembly of PHF. Six Tau protein isoforms have been identified, all of which are phosphorylated by GSK-3. This presents the possibility that miscues in GSK-3 signaling contribute to the onset of Alzheimer′s disease.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GSK-3α Antibody (9D5G1) | sc-81166 | 200 µg/ml | $310.00 |