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GSK3 beta Antibody (2Q274): sc-71188
- GSK3 beta Antibody (2Q274) is a mouse monoclonal IgG2a, cited in 1 publications, provided at 50 µg/0.5 ml
- raised against recombinant GSK-3β of Xenopus laevis origin
- recommended for detection of GSK-3β of human, rat and Xenopus origin by WB and IP
- See GSK3 alpha/beta (0011-A): sc-7291 for GSK3 beta antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for GSK3 beta Antibody (2Q274). This work is in progress.
Glycogen synthase kinase 3, or GSK-3, is a serine/threonine, proline-directed kinase involved in a diverse array of signaling pathways, including glycogen synthesis and cellular adhesion, and has been implicated in Alzheimer′s disease. Two forms of GSK-3, designated GSK-3α and GSK-3β, have been identified and differ in their subcellular localization. Tau, a microtubule-binding protein which serves to stabilize microtubules in growing axons, is found to be hyper-phosphorylated in paired helical filaments (PHF), the major fibrous component of neurofibrillary lesions associated with Alzheimer′s disease. Hyperphosphorylation of Tau is thought to be the critical event leading to the assembly of PHF. Six Tau protein isoforms have been identified, all of which are phosphorylated by GSK-3. This presents the possibility that miscues in GSK-3 signaling contribute to the onset of Alzheimer′s disease.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GSK3 beta Antibody (2Q274) | sc-71188 | 50 µg/0.5 ml | $310.00 |