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p-GSK3 beta Antibody (2D3): sc-81494
- p-GSK3 beta Antibody (2D3) is a mouse monoclonal IgG1, cited in 11 publications, provided at 50 µg/0.5 ml
- raised against phosphopeptide corresponding to amino acid residues surrounding serine 9 of GSK-3β of human origin
- recommended for detection of Ser 9 phosphorylated GSK-3β of mouse, rat and human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for p-GSK3 beta Antibody (2D3). This work is in progress.
Glycogen synthase kinase-3α (GSK-3α) and GSK-3β are highly similar isoforms of serine/ threonine kinases that regulate metabolic enzymes and transcription factors, which are responsible for coordinating processes such as glycogen synthesis and cell adhesion. GSK-3β activity is also required for nuclear activity of Rel dimers, which mediate an anti-apoptotic response to TNFα in mice. GSK-3 catalytic kinase activity is controlled through differential phosphorylation of serine/threonine residues, which have an inhibitory effect, and tyrosine residues, which have an activating effect. Growth factor stimulation of mammalian cells expressing GSK-3α and GSK-3β induces phosphorylation of Ser 21 and Ser 9, respectively, through a phosphatidylinositol 3-kinase (PI 3-K)-protein kinase B (PKB)-dependent pathway, thereby enhancing proliferative signals. Additionally, GSK-3 physically associates with cAMP-dependent protein kinase A (PKA), which phosphorylates Ser 21 of GSK-3α or Ser 9 of GSK-3β and inactivates both forms. GSK-3α/β is positively regulated by phosphorylation on Tyr 279 and Tyr 216, respectively. Activated GSK-3α/β participates in energy metabolism, neuronal cell development, and body pattern formation. Tyrosine dephosphorylation of GSK-3 is involved in its extracellular signal-dependent inactivation.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
p-GSK3 beta Antibody (2D3) | sc-81494 | 50 µg/0.5 ml | $310.00 |