PGM 3 Antibody (D-4): sc-390239

PGM 3 Antibody (D-4) is an IgG₁ κ mouse monoclonal PGM 3 antibody (also designated PGM 3 antibody) that detects the PGM 3 protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. PGM 3 Antibody (D-4) is available as both the non-conjugated anti-PGM 3 antibody form, as well as multiple conjugated forms of anti-PGM 3 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor^® conjugates. Phosphoglucomutase (PGM), which belongs to the hexose-phosphate mutase family, plays an essential role in glycogen catabolism (glycogenolysis) as well as in the process of glycogen synthesis (glycogenesis). During glycogenolysis, PGM converts glucose-1-phosphate (Glc-1-P) to glucose-6-phosphate (Glc-6-P), thus promoting glycolysis and the pentose phosphate pathway. During glycogenesis, PGM functions in the opposite manner, converting glucose-6-phosphate into glucose-1-phosphate, to facilitate glycogen synthesis. PGM has five structural loci: PGM 1, PGM 2, PGM 3, PGM 4 and Aciculin. These five genetic forms of PGM differ in amino acid sequences but catalyze the same reactions, therefore indicating that they are isozymes. PGM 3 is a 542 amino acid protein expressed ubiquitously with the exception of lung tissue. Highest level of expression is found in heart, liver, pancreas and placenta tissue. All phosphoglucomutases act as monomers and bind one magnesium ion per subunit.

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References:

1. Identification of human phosphoglucomutase 3 (PGM3) as N-acetylglucosamine-phosphate mutase (AGM1).  |  Pang, H., et al. 2002. Ann Hum Genet. 66: 139-44. PMID: 12174217
2. Phosphoglucomutase 1: complete human and rabbit mRNA sequences and direct mapping of this highly polymorphic marker on human chromosome 1.  |  Whitehouse, DB., et al. 1992. Proc Natl Acad Sci U S A. 89: 411-5. PMID: 1530890
3. Cloning and characterization of the phosphoglucomutase of Trypanosoma cruzi and functional complementation of a Saccharomyces cerevisiae PGM null mutant.  |  Penha, LL., et al. 2005. Glycobiology. 15: 1359-67. PMID: 16037487
4. Streptococcus iniae phosphoglucomutase is a virulence factor and a target for vaccine development.  |  Buchanan, JT., et al. 2005. Infect Immun. 73: 6935-44. PMID: 16177373
5. Overexpression of Mycobacterium tuberculosis manB, a phosphomannomutase that increases phosphatidylinositol mannoside biosynthesis in Mycobacterium smegmatis and mycobacterial association with human macrophages.  |  McCarthy, TR., et al. 2005. Mol Microbiol. 58: 774-90. PMID: 16238626
6. Lithium induces phosphoglucomutase activity in various tissues of rats and in bipolar patients.  |  Csutora, P., et al. 2006. Int J Neuropsychopharmacol. 9: 613-9. PMID: 16259646
7. Increased phosphoglucomutase activity suppresses the galactose growth defect associated with elevated levels of Ras signaling in S. cerevisiae.  |  Howard, SC., et al. 2006. Curr Genet. 49: 1-6. PMID: 16292676
8. Linkage and association studies of two phosphoglucomutase loci (PGM1 and PGM3) to eighteen other markers. Analysis of the segregation at the marker loci.  |  Lamm, LU., et al. 1970. Hum Hered. 20: 305-18. PMID: 4099123
9. A phylogeny for the principal alleles of the human phosphoglucomutase-1 locus.  |  Takahashi, N., et al. 1982. Proc Natl Acad Sci U S A. 79: 6636-40. PMID: 6216484

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PGM 3 Antibody (D-4) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-PGM 3 Antibody (D-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PGM 3 Antibody (D-4) Specifications

Alternate Product Name

PGM 3

Product Clone Name

D-4

Classification

Primary Antibody

Clonality

Monoclonal Antibody

Antibody Isotype

IgG₁ kappa light chain

Amino Acids

243-542

Epitope Target

PGM 3

Epitope Species

human

Product Reactivity/Detection

PGM 3

Species Reactivity/Detection

mouse, rat, human

Additional Mammalian Reactivity

N/A

Additional Non-Mammalian Reactivity

N/A

Applications

WB, IP, IF, IHC(P), ELISA

Vialing Information

Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations

1 citations in various scientific publications

Recommended Secondary Detection Reagents


Mouse IgG₁ Binding Proteins

• m-IgG₁ BP-HRP: sc-525408 (Mouse IgG₁ binding protein conjugated to horseradish peroxidase)
• m-IgG₁ BP-B: sc-533660 (Mouse IgG₁ binding protein conjugated to biotin)
• m-IgG₁ BP-FITC: sc-533659 (Mouse IgG₁ binding protein conjugated to fluorescein isothiocyanate)
• m-IgG₁ BP-CFL 488: sc-533661 (Mouse IgG₁ binding protein conjugated to CruzFluor™ 488)
• m-IgG₁ BP-CFL 555: sc-533662 (Mouse IgG₁ binding protein conjugated to CruzFluor™ 555)
• m-IgG₁ BP-CFL 594: sc-533663 (Mouse IgG₁ binding protein conjugated to CruzFluor™ 594)
• m-IgG₁ BP-CFL 647: sc-533664 (Mouse IgG₁ binding protein conjugated to CruzFluor™ 647)
• m-IgG₁ BP-CFL 680: sc-533665 (Mouse IgG₁ binding protein conjugated to CruzFluor™ 680)
• m-IgG₁ BP-CFL 790: sc-533666 (Mouse IgG₁ binding protein conjugated to CruzFluor™ 790)

Available Conjugates/Forms

AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin