HGF Antibody (24612.111): sc-57193

HGF Antibody (24612.111) is an IgG₁ mouse monoclonal HGF antibody (also designated Hepatocyte growth factor antibody) that detects the HGF protein of human origin by . HGF Antibody (24612.111) is available as the non-conjugated anti-HGF antibody. Hepatocyte growth factor (HGF) is a pleiotropic growth factor also designated scatter factor, hematopoietin A and mammary growth factor. HGF is synthesized as a single chain, 728 amino acid precursor with a 29 amino acid signal peptide which is not present in the mature protein. Biologically active HGF is composed of a disulfide linked β chain and a β chain, both of which are highly glycosylated. HGF exerts its biological effects through the HGF receptor, c-Met, which is expressed by normal hepatocytes, gastric and intestinal epithelium, ovarian and endometrial endothelium and in the basal layers of skin. While c-Met is not thought to be expressed in normal lung, thyroid or pancreatic tissue, it has been detected in tumors originating from such tissue. The c-Met proto-oncogene encodes a 1,408 amino acid glycoprotein that represents the prototypic member of a novel family of receptor tyrosine kinases (RTKs) that include Ron, Sea and Sex.

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References:

1. HGF/SF: a potent cytokine for mammary growth, morphogenesis and development.  |  Niranjan, B., et al. 1995. Development. 121: 2897-908. PMID: 7555716
2. Biological activation of pro-HGF (hepatocyte growth factor) by urokinase is controlled by a stoichiometric reaction.  |  Naldini, L., et al. 1995. J Biol Chem. 270: 603-11. PMID: 7822285
3. The Met/HGF receptor is over-expressed in human osteosarcomas and is activated by either a paracrine or an autocrine circuit.  |  Ferracini, R., et al. 1995. Oncogene. 10: 739-49. PMID: 7862451
4. Proteolytic activation of hepatocyte growth factor in response to tissue injury.  |  Miyazawa, K., et al. 1994. J Biol Chem. 269: 8966-70. PMID: 8132634
5. Coexpression of hepatocyte growth factor and receptor (Met) in human breast carcinoma.  |  Tuck, AB., et al. 1996. Am J Pathol. 148: 225-32. PMID: 8546209
6. Expression and maturation of the cellular sea receptor, a member of the hepatocyte growth factor (HGF) receptor family of protein tyrosine kinases.  |  Huff, JL., et al. 1996. Oncogene. 12: 299-307. PMID: 8570207
7. A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor.  |  Maestrini, E., et al. 1996. Proc Natl Acad Sci U S A. 93: 674-8. PMID: 8570614

The preferred HGFα antibody is HGFα Antibody (H-10): sc-374422.