IFN-α1/2/13 Antibody (ST29): sc-53341
- IFN-α1/2/13 Antibody (ST29) is a mouse monoclonal IgG1 κ IFN-α1/2/13 antibody provided at 200 µg/ml
- raised against human IFN-α
- recommended for detection of IFN-α subtypes 1, 2 and 13 of human origin by functional assay
- also provided azide-free for neutralization, sc-53341 L, 200 µg/0.1 ml
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for IFN-α1/2/13 Antibody (ST29) for WB and IHC(P) applications. This reagent is now offered in a bundle with IFN-α1/2/13 Antibody (ST29) (see ordering information below).
IFN-α1/2/13 Antibody (ST29) is an IgG1 κ mouse monoclonal IFN- alpha 1/2/13 antibody (also designated IFN-α1/2/13 antibody) that detects the IFN- alpha 1/2/13 protein of human origin by . IFN-α1/2/13 Antibody (ST29) is available as the non-conjugated anti-IFN- alpha 1/2/13 antibody. The genes encoding type I interferons (IFNs), which include 14 IFN-α genes (such as IFN-α1, IFN-α2 and IFN-α13), 1 IFN-β gene, 1 IFN-w (also known as IFN-α II1) gene and a number of IFN-w pseudogenes, are clustered on human chromosome 9. IFN-α and -β are cytokines that are widely known to induce potent antiviral activity. They exert a variety of other biological effects, including antitumor and immunomodulatory activities and are increasingly used clinically to treat a range of malignancies, myelodysplasias and autoimmune diseases. IFN-w is antigenically different from human IFN-α, IFN-β or IFN-γ, but is a component of natural mixtures of IFN species produced by virus-induced leukocytes or Burkitt′s lymphoma cells. The type I interferon receptor (IFN-αR) interacts with IFN-α, IFN-β and IFN-w, and seems to be a multisubunit receptor.
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References:
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- Expression of interferon-alpha (IFN-alpha) receptor 2c at diagnosis is associated with cytogenetic response in IFN-alpha-treated chronic myeloid leukemia. | Barthe, C., et al. 2001. Blood. 97: 3568-73. PMID: 11369652
- Bi-phasic effect of interferon (IFN)-alpha: IFN-alpha up- and down-regulates interleukin-4 signaling in human T cells. | Eriksen, KW., et al. 2004. J Biol Chem. 279: 169-76. PMID: 14559900
- Up-regulation of the interferon gamma (IFN-gamma)-inducible chemokines IFN-inducible T-cell alpha chemoattractant and monokine induced by IFN-gamma and of their receptor CXC receptor 3 in human renal cell carcinoma. | Suyama, T., et al. 2005. Cancer. 103: 258-67. PMID: 15578685
- Antigenic structure of human interferon omega 1 (interferon alpha II1): comparison with other human interferons. | Adolf, GR. 1987. J Gen Virol. 68 (Pt 6): 1669-76. PMID: 2438379
- Intrinsic ligand binding properties of the human and bovine alpha-interferon receptors. | Lim, JK., et al. 1994. FEBS Lett. 350: 281-6. PMID: 8070579
- An anti-cytokine bioactivity assay for interferons-alpha, -beta and -omega. | Mire-Sluis, AR., et al. 1996. J Immunol Methods. 195: 55-61. PMID: 8814320
- Identification of interferon-alpha 7, -alpha 14, and -alpha 21 variants in the genome of a large human population. | Hussain, M., et al. 1996. J Interferon Cytokine Res. 16: 853-9. PMID: 8910771
- Contributions of cloned type I interferon receptor subunits to differential ligand binding. | Cutrone, EC. and Langer, JA. 1997. FEBS Lett. 404: 197-202. PMID: 9119063
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IFN-α1/2/13 Antibody (ST29) | sc-53341 | 200 µg/ml | $310.00 | |||
IFN-α1/2/13 Antibody (ST29): m-IgG Fc BP-HRP Bundle | sc-538985 | 200 µg Ab; 10 µg BP | $348.00 | |||
IFN-α1/2/13 Antibody (ST29) L | sc-53341 L | 200 µg/0.1 ml | $310.00 |