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IL-3/IL-5/GM-CSFRβ Antibody (8E4): sc-21766
- IL-3/IL-5/GM-CSFRβ Antibody (8E4) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- raised against IL-3/IL-5/GM-CSFRβ of human origin
- recommended for detection of 130 kDa β chain common to IL-3R, IL-5R and GM-CSFR of human origin by IP and FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for IL-3/IL-5/GM-CSFRβ Antibody (8E4) for WB and IHC(P) applications. These reagents are now offered in bundles with IL-3/IL-5/GM-CSFRβ Antibody (8E4) (see ordering information below).
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Interleukin-3, or IL-3, is a pleiotropic cytokine that is primarily secreted by activated T lymphocytes and stimulates the proliferation and differentiation of hematopoietic cells. IL-3 not only supports growth of both pluripotent stem cells and the more differentiated committed progenitors, but it also stimulates the functional activity of some fully differentiated cells. IL-3 has also been shown to protect mast cells from undergoing apoptosis. IL-3 exerts its biological effects through a receptor which consists of a ligand-specific α subunit and a signal transducing β subunit common to the IL-3/IL-5/GM-CSF receptors. The carboxy terminus of the β subunit has been shown to be necessary for activation of the MAP kinase signaling pathway. Although the IL-3 receptor has no intrinsic kinase activity, stimulation with IL-3 leads to tyrosine phosphorylation of the JAK/Tyk 2 family member, JAK2, which in turn activates and causes nuclear translocation of Stat5a and Stat5b.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IL-3/IL-5/GM-CSFRβ Antibody (8E4) | sc-21766 | 200 µg/ml | $310.00 | |||
IL-3/IL-5/GM-CSFRβ Antibody (8E4): m-IgG Fc BP-HRP Bundle | sc-536664 | 200 µg Ab; 10 µg BP | $348.00 | |||
IL-3/IL-5/GM-CSFRβ Antibody (8E4): m-IgGκ BP-HRP Bundle | sc-533823 | 200 µg Ab; 40 µg BP | $348.00 | |||
IL-3/IL-5/GM-CSFRβ Antibody (8E4): m-IgG1 BP-HRP Bundle | sc-544748 | 200 µg Ab; 20 µg BP | $348.00 | |||
IL-3/IL-5/GM-CSFRβ Antibody (8E4) FITC | sc-21766 FITC | 200 µg/ml | $324.00 | |||
IL-3/IL-5/GM-CSFRβ Antibody (8E4) PE | sc-21766 PE | 200 µg/ml | $337.00 |