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PAR-2 Antibody (3G233): sc-71842
- PAR-2 Antibody (3G233) is a mouse monoclonal IgG2a κ, cited in 1 publications, provided at 200 µg/ml
- epitope mapping within amino acids 37-50 of PAR-2 of human origin
- recommended for detection of PAR-2 of mouse, rat and human origin by WB, IP, IF and FCM
- See PAR-2 (SAM11): sc-13504 for PAR-2 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for PAR-2 Antibody (3G233) for WB applications. These reagents are now offered in bundles with PAR-2 Antibody (3G233) (see ordering information below).
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Thrombin receptor (also designated protease-activated receptor-1 or PAR-1), PAR-2 and PAR-3 compose a distinct class of G protein-coupled receptors activated by proteolysis. Cleavage of these receptors by proteases occurs within the amino-terminal extracellular domain. Thrombin, a serine protease involved in platelet aggregation and blood coagulation, activates the thrombin receptor, resulting in elevated intracellular calcium levels in platelets. Thrombin also cleaves PAR-3 in vitro, suggesting that PAR-3 may be involved in thrombosis or mitogenesis. Thrombin receptor and PAR-4 appear to account for most thrombin signaling in platelets. Activation of PAR-2 in vitro is induced by trypsin, suggesting that PAR-2 is not an alternative thrombin receptor (2,6). Cytokines including TNF-α and IL-1β increase PAR-2 expression, indicating PAR-2 involvement in the acute inflammatory response.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PAR-2 Antibody (3G233) | sc-71842 | 200 µg/ml | $310.00 | |||
PAR-2 Antibody (3G233): m-IgG Fc BP-HRP Bundle | sc-539416 | 200 µg Ab; 10 µg BP | $348.00 | |||
PAR-2 Antibody (3G233): m-IgG2a BP-HRP Bundle | sc-546700 | 200 µg Ab; 10 µg BP | $348.00 |