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pan 14-3-3 Antibody (F-1): sc-166061
- pan 14-3-3 Antibody (F-1) is a mouse monoclonal IgG2b κ provided at 200 µg/ml
- raised against amino acids 1-246 representing full length 14-3-3 β of human origin
- recommended for detection of pan 14-3-3 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including bovine
- See pan 14-3-3 (B-8): sc-133233 for pan 14-3-3 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for pan 14-3-3 Antibody (F-1) for WB and IHC(P) applications. These reagents are now offered in bundles with pan 14-3-3 Antibody (F-1) (see ordering information below).
14-3-3 proteins regulate many cellular processes relevant to cancer biology, notably apoptosis, mitogenic signaling and cell-cycle checkpoints. Seven isoforms comprise this family of signaling intermediates, denoted 14-3-3 β, γ, ε, ζ, η, θ and Σ. 14-3-3 proteins form dimers that present two binding sites for ligand proteins, thereby bringing together two proteins that may not otherwise associate. These ligands largely share a 14-3-3 consensus binding motif and exhibit serine/threonine phosphorylation. 14-3-3 proteins function in broad regulation of these ligand proteins, by cytoplasmic sequestration, occupation of interaction domains and import/export sequences, prevention of degradation, activation/repression of enzymatic activity and facilitation of protein modification, and thus loss of expression contributes to a vast array of pathogenic cellular activities.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
pan 14-3-3 Antibody (F-1) | sc-166061 | 200 µg/ml | $310.00 | |||
pan 14-3-3 Antibody (F-1): m-IgGκ BP-HRP Bundle | sc-534701 | 200 µg Ab; 40 µg BP | $348.00 | |||
pan 14-3-3 Antibody (F-1): m-IgG2b BP-HRP Bundle | sc-549283 | 200 µg Ab; 10 µg BP | $348.00 |