Adenylate cyclase 8/AC8/ADCY8 Antibody (B-4): sc-377442

Adenylyl cyclases function to convert ATP to cyclic AMP in response to activation by a variety of hormones, neurotransmitters and other regulatory molecules. Adenylyl cyclases respond to receptor-initiated signals, mediated by the Gs and Gi heterotrimeric G proteins. The binding of an agonist to a Gs-coupled receptor catalyzes the exchange of GDP (bound to Ga s) for GTP, dissociation of GTP-Gα s from Gβ γ and Gα s-mediated activation of adenylyl cyclase. Adenylyl cyclase type VIII (A cyclase VIII) is one of the three mammalian calcium-stimulated isoforms, each of which is expressed in a region-specific manner in the central nervous system. In addition to the high expression in the brain, A cyclase VIII is also expressed in the lung. Ca2+/calmodulin-dependent A cyclase VIII immunoreactivity is increased in alcoholic corpus amyadaloideum and hippocampus, suggesting that adenyl cyclase may play a role in the pathophysiology of alcoholism. A significant decrease in the level of A cyclase I and a tendency to decrease in the level of A cyclase VIII in Alzheimer′s disease hippocampus suggests that A cyclase I and VIII may play an essential role in learning and memory. A cyclase VIII knock-out mice do not have normal increases in behavioral markers of anxiety; thus, A cyclase VIII may also function in the modulation of anxiety.

The preferred Adenylate cyclase 8/AC8/ADCY8 antibody is Adenylate cyclase 8/AC8/ADCY8 Antibody (B-6): sc-377323.