Click on image or enlarge button to enlarge
Cbl-b Antibody (B-5) is an IgG2b κ mouse monoclonal Cbl-b antibody (also designated Cbl-b antibody or CBLB antibody) that detects Cbl-b of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. Cbl-b Antibody (B-5) is available as the non-conjugated anti-Cbl-b antibody form, as well as multiple conjugated forms of anti-Cbl-b antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Cbl (also designated the c-Cbl proto-oncogene, E3 ubiquitin-protein ligase CBL, Casitas B-lineage lymphoma proto-oncogene, and RING finger protein 55) has been identified as the cellular homolog of the v-Cbl oncogene isolated from an NFS/N mouse that developed a pre-B cell lymphoma following infection with the replication-competent Cas Br-M murine leukemic virus. c-Cbl is expressed at relatively high levels in a wide range of hematopoietic tumor cell lines as well as in normal tissues such as thymus and testis. The c-Cbl gene product has been identified as a cytoplasmic protein with apparent DNA binding and dimerization domains characteristic of transcription factors. A single c-Cbl locus termed CBL2 has been mapped to human chromosome 11q23. This region of chromosome 11 is involved in translocations and deletions in a broad range of leukemias; c-Cbl has been found to be translocated from chromosome 11 in leukemias with either t(4;11) or t(11;14) abnormalities. Two proteins related to c-Cbl have been identified as Cbl-b (RING finger protein 56) and Cbl-3 (RING finger protein 57). Cbl-b has a proline-rich domain, a nuclear localization signal, a C3HC4 zinc finger and a putative leucine zipper. Cbl-b is expressed in normal and malignant mammary epithelial cells, various normal tissues and hematopoietic tissue and cell lines. Data suggests that Cbl-b encodes a protein that can interact with signal transduction proteins to regulate their function or be regulated by them.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ordering Information
Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cbl-b Antibody (B-5) | sc-376409 | 200 µg/ml | $310.00 | |||
Cbl-b Antibody (B-5): m-IgGκ BP-HRP Bundle | sc-522948 | 200 µg Ab, 40 µg BP | $348.00 | |||
Cbl-b Antibody (B-5) AC | sc-376409 AC | 500 µg/ml, 25% agarose | $408.00 | |||
Cbl-b Antibody (B-5) HRP | sc-376409 HRP | 200 µg/ml | $310.00 | |||
Cbl-b Antibody (B-5) FITC | sc-376409 FITC | 200 µg/ml | $324.00 | |||
Cbl-b Antibody (B-5) PE | sc-376409 PE | 200 µg/ml | $337.00 | |||
Cbl-b Antibody (B-5) Alexa Fluor® 488 | sc-376409 AF488 | 200 µg/ml | $350.00 | |||
Cbl-b Antibody (B-5) Alexa Fluor® 546 | sc-376409 AF546 | 200 µg/ml | $350.00 | |||
Cbl-b Antibody (B-5) Alexa Fluor® 594 | sc-376409 AF594 | 200 µg/ml | $350.00 | |||
Cbl-b Antibody (B-5) Alexa Fluor® 647 | sc-376409 AF647 | 200 µg/ml | $350.00 | |||
Cbl-b Antibody (B-5) Alexa Fluor® 680 | sc-376409 AF680 | 200 µg/ml | $350.00 | |||
Cbl-b Antibody (B-5) Alexa Fluor® 790 | sc-376409 AF790 | 200 µg/ml | $350.00 | |||
Cbl-b (B-5) Neutralizing Peptide | sc-376409 P | 100 µg/0.5 ml | $67.00 |