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CYP3A1 Antibody (4i69): sc-70903
- CYP3A1 Antibody (4i69) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- raised against rat liver cytochrome P450 3A1
- recommended for detection of CYP3A4 of human origin, Cyp3a1 of rat origin, and potentially Cyp3a11 of mouse origin (based on inducibility) by WB and IP; may cross-react with other CYP3A gene family members of mouse, rat and human origin
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CYP3A1 Antibody (4i69) for WB applications. These reagents are now offered in bundles with CYP3A1 Antibody (4i69) (see ordering information below).
CYP3A proteins are P450 monooxygenases and in animals, P450 enzymes serve two major functions: biosynthesis of steroids, fatty acids and bile acids, and the metabolism of endogenous and exogenous substrates. A wide variety of exogenous substrates are metabolized by P450 enzymes, including toxins and drugs. The four major families involved in drug metabolism are CYP1, 2, 3 and 4. Cyp3a1, also designated Cyp3a23/3a1 is specifically expressed in rat. There are corresponding homologs described in human and mouse, including CYP3A5 and Cyp3a11, respectively. In humans, CYP3A4 undergoes alternative splicing encoding different isoforms, including one previously designated CYP3A3. CYP3A4 localizes to the endoplasmic reticulum in liver and small intestine, and its expression is induced by glucocorticoids and some pharmacological agents.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CYP3A1 Antibody (4i69) | sc-70903 | 200 µg/ml | $310.00 | |||
CYP3A1 Antibody (4i69): m-IgG Fc BP-HRP Bundle | sc-537196 | 200 µg Ab; 10 µg BP | $348.00 | |||
CYP3A1 Antibody (4i69): m-IgGκ BP-HRP Bundle | sc-534403 | 200 µg Ab; 40 µg BP | $348.00 | |||
CYP3A1 Antibody (4i69): m-IgG1 BP-HRP Bundle | sc-545071 | 200 µg Ab; 20 µg BP | $348.00 |