Click on image or enlarge button to enlarge
GALK1 Antibody (A-2): sc-393404
- GALK1 Antibody (A-2) is a mouse monoclonal IgG1 κ GALK1 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 18-43 at the N-terminus of GALK1 of human origin
- GALK1 Antibody (A-2) is recommended for detection of GALK1 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-GALK1 Antibody (A-2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of GALK1 (A-2): sc-393404.
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for GALK1 Antibody (A-2) for WB applications. These reagents are now offered in bundles with GALK1 Antibody (A-2) (see ordering information below).
QUICK LINKS
GALK1 Antibody (A-2) is an IgG1 κ mouse monoclonal GALK1 antibody (also designated GALK1 antibody) that detects the GALK1 protein of mouse, rat and human origin by WB, IP, IF and ELISA. GALK1 Antibody (A-2) is available as both the non-conjugated anti-GALK1 antibody form, as well as multiple conjugated forms of anti-GALK1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Galactose kinase (GALK1), also often designated galactokinase, is important in the first step of the galactose metabolism pathway. GALK1, which belongs to the GHMP kinase family of proteins, is a crucial enzyme for galactose metabolism. Defects in the gene encoding for galactose kinase, GALK1, can cause galactosemia II, an autosomal recessive disorder characterized by congenital cataracts during infancy, often within the first two weeks of life. In the adult population it can cause presenile cataracts that are secondary to accumulation of galactitol in the lens of the eye.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
References:
- Novel mutations in the GALK1 gene in patients with galactokinase deficiency. | Hunter, M., et al. 2001. Hum Mutat. 17: 77-8. PMID: 11139256
- A genetic factor for age-related cataract: identification and characterization of a novel galactokinase variant, ′Osaka,′ in Asians. | Okano, Y., et al. 2001. Am J Hum Genet. 68: 1036-42. PMID: 11231902
- Functional analysis of disease-causing mutations in human galactokinase. | Timson, DJ. and Reece, RJ. 2003. Eur J Biochem. 270: 1767-74. PMID: 12694189
- Biochemical characterization of two GALK1 mutations in patients with galactokinase deficiency. | Sangiuolo, F., et al. 2004. Hum Mutat. 23: 396. PMID: 15024738
- Differential roles of the Leloir pathway enzymes and metabolites in defining galactose sensitivity in yeast. | Ross, KL., et al. 2004. Mol Genet Metab. 83: 103-16. PMID: 15464425
- Galactokinase: structure, function and role in type II galactosemia. | Holden, HM., et al. 2004. Cell Mol Life Sci. 61: 2471-84. PMID: 15526155
- Molecular structure of human galactokinase: implications for type II galactosemia. | Thoden, JB., et al. 2005. J Biol Chem. 280: 9662-70. PMID: 15590630
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GALK1 Antibody (A-2) | sc-393404 | 200 µg/ml | $310.00 | |||
GALK1 Antibody (A-2): m-IgG Fc BP-HRP Bundle | sc-530445 | 200 µg Ab; 10 µg BP | $348.00 | |||
GALK1 Antibody (A-2): m-IgGκ BP-HRP Bundle | sc-523932 | 200 µg Ab, 40 µg BP | $348.00 | |||
GALK1 Antibody (A-2): m-IgG1 BP-HRP Bundle | sc-544056 | 200 µg Ab; 20 µg BP | $348.00 | |||
GALK1 Antibody (A-2) AC | sc-393404 AC | 500 µg/ml, 25% agarose | $408.00 | |||
GALK1 Antibody (A-2) HRP | sc-393404 HRP | 200 µg/ml | $310.00 | |||
GALK1 Antibody (A-2) FITC | sc-393404 FITC | 200 µg/ml | $324.00 | |||
GALK1 Antibody (A-2) PE | sc-393404 PE | 200 µg/ml | $337.00 | |||
GALK1 Antibody (A-2) Alexa Fluor® 488 | sc-393404 AF488 | 200 µg/ml | $350.00 | |||
GALK1 Antibody (A-2) Alexa Fluor® 546 | sc-393404 AF546 | 200 µg/ml | $350.00 | |||
GALK1 Antibody (A-2) Alexa Fluor® 594 | sc-393404 AF594 | 200 µg/ml | $350.00 | |||
GALK1 Antibody (A-2) Alexa Fluor® 647 | sc-393404 AF647 | 200 µg/ml | $350.00 | |||
GALK1 Antibody (A-2) Alexa Fluor® 680 | sc-393404 AF680 | 200 µg/ml | $350.00 | |||
GALK1 Antibody (A-2) Alexa Fluor® 790 | sc-393404 AF790 | 200 µg/ml | $350.00 | |||
GALK1 (A-2) Neutralizing Peptide | sc-393404 P | 100 µg/0.5 ml | $67.00 |