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Int-6 Antibody (A-8): sc-74505
- Int-6 Antibody (A-8) is a mouse monoclonal IgG2a κ, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 246-445 mapping at the C-terminus of Int-6 of human origin
- recommended for detection of Int-6 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for Int-6 Antibody (A-8) for WB applications. These reagents are now offered in bundles with Int-6 Antibody (A-8) (see ordering information below).
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SEE ALSO...
Int-6, also designated eIF3e, eIF3-p46, eIF3-p48 and eukaryotic translation initiation factor 3, subunit 6, regulates translation and protein degradation through binding with three complexes: the eukaryotic translation initiation factor 3 (eIF3), the proteasome regulatory lid and the constitutive photomorphogenesis 9 signalosome. eIF3 is a complex that mediates assembly of 40S ribosomal subunits on mRNA bearing either a 5′-cap or an internal ribosome entry site (IRES). The Int-6 gene is a site of mouse mammary tumour virus (MMTV) integration in murine tumors. Reducing Int-6 expression by RNA interference in HeLa cells alters mitosis progression through defects in spindle formation, chromosome segregation and cytokinesis. These abberations appear to correlate with an inhibition of cyclin B-Cdk1 kinase activity, due to a protracted inhibitory phosphorylated state of Cdk1.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Int-6 Antibody (A-8) | sc-74505 | 200 µg/ml | $310.00 | |||
Int-6 Antibody (A-8): m-IgG Fc BP-HRP Bundle | sc-539535 | 200 µg Ab; 10 µg BP | $348.00 | |||
Int-6 Antibody (A-8): m-IgG2a BP-HRP Bundle | sc-546725 | 200 µg Ab; 10 µg BP | $348.00 |