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MDHC Antibody (H-6): sc-166879
- MDHC Antibody (H-6) is a mouse monoclonal IgG1 κ MDHC antibody, cited in 5 publications, provided at 200 µg/ml
- raised against amino acids 255-320 mapping near the C-terminus of MDHC of human origin
- MDHC Antibody (H-6) is recommended for detection of MDHC (malate dehydrogenase, cytoplasmic) of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-MDHC Antibody (H-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of MDHC (H-6): sc-166879.
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for MDHC Antibody (H-6) for WB and IHC(P) applications. These reagents are now offered in bundles with MDHC Antibody (H-6) (see ordering information below).
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SEE ALSO...
MDHC Antibody (H-6) is an IgG1 κ mouse monoclonal MDHC antibody (also designated MDHC antibody) that detects the MDHC protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. MDHC Antibody (H-6) is available as both the non-conjugated anti-MDHC antibody form, as well as multiple conjugated forms of anti-MDHC antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Cytosolic malate dehydrogenase (MDHC or cMDH) is an important NAD-dependent enzyme involved in glycometabolism that catalyzes the formation of oxaloacetate and NADH from L-malate and NAD. MDHC is highly expressed in brain, heart and skeletal muscle and plays a role in aerobic energy production for muscle contraction, transmission of neuronal signals, absorption/ resorption pathways, collagen-supporting functions, dead cell phagocytosis, as well as pathways involved in gas exchange and cell division. Furthermore, MDHC is a regulatory subunit of the nucleic acid-conducting channel (NACh). MDHC functions as a homodimer and is highly conserved in plants, animals and bacteria. The activity of MDHC is controlled by the sesquiterpenoid juvenile hormone (JH) and the steroid hormone ecdysone.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
References:
- Ability of cytosolic malate dehydrogenase and lactate dehydrogenase to increase the ratio of NADPH to NADH oxidation by cytosolic glycerol-3-phosphate dehydrogenase. | Fahien, LA., et al. 1999. Arch Biochem Biophys. 364: 185-94. PMID: 10190973
- Cytosolic malate dehydrogenase confers selectivity of the nucleic acid-conducting channel. | Hanss, B., et al. 2002. Proc Natl Acad Sci U S A. 99: 1707-12. PMID: 11805283
- Evolution of the vertebrate cytosolic malate dehydrogenase gene family: duplication and divergence in actinopterygian fish. | Merrit, TJ. and Quattro, M. 2003. J Mol Evol. 56: 265-76. PMID: 12612830
- dl-alpha-lipoic acid ameliorates cyclophosphamide induced cardiac mitochondrial injury. | Mythili, Y., et al. 2005. Toxicology. 215: 108-14. PMID: 16085348
- Genetic variability among beech (Fagus sylvatica L.) populations from the Sudety Mountains, in respect of peroxidase and malate dehydrogenase loci. | Krzakowa, M. and Matras, J. 2005. J Appl Genet. 46: 271-7. PMID: 16110183
- Modulation of TCA cycle enzymes and electron transport chain systems in experimental lung cancer. | Senthilnathan, P., et al. 2006. Life Sci. 78: 1010-4. PMID: 16143346
- Neutron scattering reveals the dynamic basis of protein adaptation to extreme temperature. | Tehei, M., et al. 2005. J Biol Chem. 280: 40974-9. PMID: 16203729
- Isolation and characterization of cytosolic malate dehydrogenase from Trichomonas vaginalis. | Drmota, T., et al. 1997. Folia Parasitol (Praha). 44: 103-8. PMID: 9269720
- Genetic and hormonal control of cytosolic malate dehydrogenase activity in Drosophila melanogaster. | Farkas, R. and Knopp, J. 1998. Gen Physiol Biophys. 17: 37-50. PMID: 9675555
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MDHC Antibody (H-6) | sc-166879 | 200 µg/ml | $310.00 | |||
MDHC Antibody (H-6): m-IgG Fc BP-HRP Bundle | sc-529076 | 200 µg Ab; 10 µg BP | $348.00 | |||
MDHC Antibody (H-6): m-IgGκ BP-HRP Bundle | sc-521782 | 200 µg Ab, 40 µg BP | $348.00 | |||
MDHC Antibody (H-6): m-IgG1 BP-HRP Bundle | sc-543306 | 200 µg Ab; 20 µg BP | $348.00 | |||
MDHC Antibody (H-6) AC | sc-166879 AC | 500 µg/ml, 25% agarose | $408.00 | |||
MDHC Antibody (H-6) HRP | sc-166879 HRP | 200 µg/ml | $310.00 | |||
MDHC Antibody (H-6) FITC | sc-166879 FITC | 200 µg/ml | $324.00 | |||
MDHC Antibody (H-6) PE | sc-166879 PE | 200 µg/ml | $337.00 | |||
MDHC Antibody (H-6) Alexa Fluor® 488 | sc-166879 AF488 | 200 µg/ml | $350.00 | |||
MDHC Antibody (H-6) Alexa Fluor® 546 | sc-166879 AF546 | 200 µg/ml | $350.00 | |||
MDHC Antibody (H-6) Alexa Fluor® 594 | sc-166879 AF594 | 200 µg/ml | $350.00 | |||
MDHC Antibody (H-6) Alexa Fluor® 647 | sc-166879 AF647 | 200 µg/ml | $350.00 | |||
MDHC Antibody (H-6) Alexa Fluor® 680 | sc-166879 AF680 | 200 µg/ml | $350.00 | |||
MDHC Antibody (H-6) Alexa Fluor® 790 | sc-166879 AF790 | 200 µg/ml | $350.00 |