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SDHA Antibody (C-8): sc-377302
- SDHA Antibody (C-8) is a mouse monoclonal IgG2b κ, cited in 5 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 637-664 at the C-terminus of SDHA of human origin
- recommended for detection of precursor and mature SDHA of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including porcine
- m-IgGκ BP-HRP is the preferred secondary detection reagent for SDHA Antibody (C-8) for WB applications. This reagent is now offered in a bundle with SDHA Antibody (C-8) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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In aerobic respiration reactions, succinate dehydrogenase (SDH) catalyzes the oxidation of succinate and ubiquinone to fumarate and ubiquinol. Four subunits comprise the SDH protein complex: a flavochrome subunit (SDHA), an iron-sulfur protein (SDHB), and two membrane-bound subunits (SDHC and SDHD) anchored to the inner mitochondrial membrane. Mutations to these subunits cause mitochondrial dysfunction, corresponding to several distinct disorders. Mutations in the membrane bound components may cause hereditary paraganglioma, while SDHA mutations are associated with juvenile encephalopathy as well as Leigh Syndrome, a severe neurological disorder. Inactivating mutations in SDHB correlate with inherited, but not necessarily sporadic, cases of pheochromocytoma.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SDHA Antibody (C-8) | sc-377302 | 200 µg/ml | $310.00 | |||
SDHA Antibody (C-8): m-IgGκ BP-HRP Bundle | sc-535557 | 200 µg Ab; 40 µg BP | $348.00 | |||
SDHA (C-8) Neutralizing Peptide | sc-377302 P | 100 µg/0.5 ml | $67.00 |