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Septin 1 Antibody (H-10): sc-373925
- Septin 1 Antibody (H-10) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 224-251 within an internal region of Septin 1 of human origin
- Anti-Septin 1 Antibody (H-10) is recommended for detection of Septin 1 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-Septin 1 Antibody (H-10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of Septin 1 (H-10): sc-373925.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Septin 1 Antibody (H-10) for WB applications. These reagents are now offered in bundles with Septin 1 Antibody (H-10) (see ordering information below).
Septin 1 Antibody (H-10) is an IgG1 κ mouse monoclonal Septin 1 antibody that detects Septin 1 of mouse, rat and human origin by WB, IP, IF and ELISA. Septin 1 Antibody (H-10) is available as the non-conjugated anti-Septin 1 antibody form, as well as multiple conjugated forms of anti-Septin 1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The septins are a family of GTPase enzymes, some of which are required for cytokinesis and others of which are associated with exocytosis. Members of the septin family can form heteropolymer complexes and also play a role in the organization of new growth in organisms. The transcriptional regulation of all septins is complex, resulting in alternatively spliced variants. At least three septins (Septin 1, 2 and 4) are associated with a tau-based paired helical filament core and may contribute to the formation of neurofibrillary tangle as integral constituents of paired helical filaments. Septin 3 (G-Septin), a GTP-binding protein, is highly expressed in brain and is regulated by protein kinase G in neurons. The human SEPT4 (H5/PNUTL2/CDCREL-2) gene encodes ARTS (for apoptosis-related protein in the TGF-β signaling pathway), which is expressed in many cells and acts to enhance cell death induced by TGF-β or, to a lesser extent, by other apoptotic agents. ARTS is localized to mitochondria and translocates to the nucleus when apoptosis occurs. Septin 5 is a major form of the CDCREL-1 septin in the adult neocortex of mammals. Human Septin 6 protein contains an ATP-GTP binding motif and three nuclear targeting sequences in its C-terminus. Septin 6 is the third septin member that is fused to the MLL protein, in addition to hCDCREL and MSF.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
References:
- Phosphorylation of a new brain-specific septin, G-septin, by cGMP-dependent protein kinase. | Xue, J., et al. 2000. J Biol Chem. 275: 10047-56. PMID: 10744683
- Reciprocal expression of infant- and adult-preferring transcripts of CDCrel-1 septin gene in the rat neocortex. | Toda, S., et al. 2000. Biochem Biophys Res Commun. 273: 723-8. PMID: 10873671
- Alternative exon usage of rat septins. | Jackisch, BO., et al. 2000. Biochem Biophys Res Commun. 275: 180-8. PMID: 10944462
- A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif. | Larisch, S., et al. 2000. Nat Cell Biol. 2: 915-21. PMID: 11146656
- Characterization of the Aspergillus nidulans septin (asp) gene family. | Momany, M., et al. 2001. Genetics. 157: 969-77. PMID: 11238387
- An ins(X;11)(q24;q23) fuses the MLL and the Septin 6/KIAA0128 gene in an infant with AML-M2. | Borkhardt, A., et al. 2001. Genes Chromosomes Cancer. 32: 82-8. PMID: 11477664
- Identification of septins in neurofibrillary tangles in Alzheimer′s disease. | Kinoshita, A., et al. 1998. Am J Pathol. 153: 1551-60. PMID: 9811347
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Septin 1 Antibody (H-10) | sc-373925 | 200 µg/ml | $310.00 | |||
Septin 1 Antibody (H-10): m-IgG Fc BP-HRP Bundle | sc-527424 | 200 µg Ab; 10 µg BP | $348.00 | |||
Septin 1 Antibody (H-10): m-IgG1 BP-HRP Bundle | sc-532797 | 200 µg Ab; 20 µg BP | $348.00 | |||
Septin 1 Antibody (H-10) AC | sc-373925 AC | 500 µg/ml, 25% agarose | $408.00 | |||
Septin 1 Antibody (H-10) HRP | sc-373925 HRP | 200 µg/ml | $310.00 | |||
Septin 1 Antibody (H-10) FITC | sc-373925 FITC | 200 µg/ml | $324.00 | |||
Septin 1 Antibody (H-10) PE | sc-373925 PE | 200 µg/ml | $337.00 | |||
Septin 1 Antibody (H-10) Alexa Fluor® 488 | sc-373925 AF488 | 200 µg/ml | $350.00 | |||
Septin 1 Antibody (H-10) Alexa Fluor® 546 | sc-373925 AF546 | 200 µg/ml | $350.00 | |||
Septin 1 Antibody (H-10) Alexa Fluor® 594 | sc-373925 AF594 | 200 µg/ml | $350.00 | |||
Septin 1 Antibody (H-10) Alexa Fluor® 647 | sc-373925 AF647 | 200 µg/ml | $350.00 | |||
Septin 1 Antibody (H-10) Alexa Fluor® 680 | sc-373925 AF680 | 200 µg/ml | $350.00 | |||
Septin 1 Antibody (H-10) Alexa Fluor® 790 | sc-373925 AF790 | 200 µg/ml | $350.00 | |||
Septin 1 (H-10) Neutralizing Peptide | sc-373925 P | 100 µg/0.5 ml | $67.00 |