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Dynamin II Antibody (5E4C2F3): sc-81150
- Dynamin II Antibody (5E4C2F3) is a mouse monoclonal IgG1 provided at 200 µg/ml
- raised against a recombinant protein corresponding to amino acids 520-744 of Dynamin II of human origin
- recommended for detection of Dynamin II of mouse, rat and human origin by WB, IP, IF and IHC(P)
- See Dynamin II (G-4): sc-166669 for Dynamin II antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Dynamin II Antibody (5E4C2F3). This work is in progress.
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Members of the dynamin family, including Dynamin I and Dynamin II, are GPTase, microtubule-associated proteins which are involved in endocytosis, synaptic transmission and neurogenesis. Dynamin I is localized to the central nervous system, while Dynamin II exhibits ubiquitous distribution with highest expression found in testis. Both dynamin proteins contain SH3 and proline-rich domains that mediate interactions between the dynamins and effectors of their GTPase activity. The interactions with these effectors, which include microtubules, acidic phospholipids and SH3 domain-containing proteins, are required for rapid endocytosis. Dynamin I appears to be recruited to clathrin coated pits by SH3 domain interaction with amphiphysin, a protein highly expressed in brain.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Dynamin II Antibody (5E4C2F3) | sc-81150 | 200 µg/ml | $310.00 |