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Antiquitin Antibody (A-7): sc-514167
- Antiquitin Antibody (A-7) is a mouse monoclonal IgG1 κ Antiquitin antibody provided at 200 µg/ml
- raised against amino acids 391-539 mapping at the C-terminus of Antiquitin of human origin
- Antiquitin Antibody (A-7) is recommended for detection of Antiquitin of human origin by WB, IP, IF and ELISA
- Anti-Antiquitin Antibody (A-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of Antiquitin (A-7): sc-514167.
- m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Antiquitin Antibody (A-7) for WB applications. These reagents are now offered in bundles with Antiquitin Antibody (A-7) (see ordering information below).
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Antiquitin Antibody (A-7) is an IgG1 κ mouse monoclonal Antiquitin antibody (also designated Antiquitin antibody) that detects the Antiquitin protein of human origin by WB, IP, IF and ELISA. Antiquitin Antibody (A-7) is available as both the non-conjugated anti-Antiquitin antibody form, as well as multiple conjugated forms of anti-Antiquitin antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Aldehyde dehydrogenases (ALDHs) mediate the NADP+-dependent oxidation of aldehydes into acids and play an important role in the detoxification of alcohol-derived acetaldehyde, as well as in lipid peroxidation and in the metabolism of corticosteroids, biogenic amines and neurotransmitters. Antiquitin, also known as ALDH7A1 (aldehyde dehydrogenase 7 family, member A1), ATQ1, EPD or PDE, is a 539 amino acid protein that is highly expressed in ovary, heart, eye, kidney and ear tissue and plays an important role in the detoxification of lipid peroxidation- and alcohol metabolism-related aldehydes. Mutations in the gene encoding Antiquitin are the cause of pyridoxine-dependent epilepsy (PDE), a rare disorder that is characterized by seizures that begin at infancy and involve muscle rigidity, convulsions and loss of consciousness. Additionally, PDE is associated with poor muscle tone, hypothermia and irritability.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
References:
- Mutations in antiquitin in individuals with pyridoxine-dependent seizures. | Mills, PB., et al. 2006. Nat Med. 12: 307-9. PMID: 16491085
- Biochemical and molecular characterization of 18 patients with pyridoxine-dependent epilepsy and mutations of the antiquitin (ALDH7A1) gene. | Plecko, B., et al. 2007. Hum Mutat. 28: 19-26. PMID: 17068770
- Pyridoxine-dependent seizures in Dutch patients: diagnosis by elevated urinary alpha-aminoadipic semialdehyde levels. | Bok, LA., et al. 2007. Arch Dis Child. 92: 687-9. PMID: 17088338
- Allelic and non-allelic heterogeneities in pyridoxine dependent seizures revealed by ALDH7A1 mutational analysis. | Kanno, J., et al. 2007. Mol Genet Metab. 91: 384-9. PMID: 17433748
- An intriguing ′silent′ mutation and a founder effect in antiquitin (ALDH7A1). | Salomons, GS., et al. 2007. Ann Neurol. 62: 414-8. PMID: 17721876
- Mutations in the ALDH7A1 gene cause pyridoxine-dependent seizures. | Been, JV., et al. 2008. Arq Neuropsiquiatr. 66: 288; author reply 288-9. PMID: 18545806
- Prevalence of ALDH7A1 mutations in 18 North American pyridoxine-dependent seizure (PDS) patients. | Bennett, CL., et al. 2009. Epilepsia. 50: 1167-75. PMID: 19128417
- An ancient conserved gene expressed in the human inner ear: identification, expression analysis, and chromosomal mapping of human and mouse antiquitin (ATQ1). | Skvorak, AB., et al. 1997. Genomics. 46: 191-9. PMID: 9417906
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Antiquitin Antibody (A-7) | sc-514167 | 200 µg/ml | $310.00 | |||
Antiquitin Antibody (A-7): m-IgGκ BP-HRP Bundle | sc-524633 | 200 µg Ab, 40 µg BP | $348.00 | |||
Antiquitin Antibody (A-7): m-IgG1 BP-HRP Bundle | sc-533634 | 200 µg Ab; 20 µg BP | $348.00 | |||
Antiquitin Antibody (A-7) AC | sc-514167 AC | 500 µg/ml, 25% agarose | $408.00 | |||
Antiquitin Antibody (A-7) HRP | sc-514167 HRP | 200 µg/ml | $310.00 | |||
Antiquitin Antibody (A-7) FITC | sc-514167 FITC | 200 µg/ml | $324.00 | |||
Antiquitin Antibody (A-7) PE | sc-514167 PE | 200 µg/ml | $337.00 | |||
Antiquitin Antibody (A-7) Alexa Fluor® 488 | sc-514167 AF488 | 200 µg/ml | $350.00 | |||
Antiquitin Antibody (A-7) Alexa Fluor® 546 | sc-514167 AF546 | 200 µg/ml | $350.00 | |||
Antiquitin Antibody (A-7) Alexa Fluor® 594 | sc-514167 AF594 | 200 µg/ml | $350.00 | |||
Antiquitin Antibody (A-7) Alexa Fluor® 647 | sc-514167 AF647 | 200 µg/ml | $350.00 | |||
Antiquitin Antibody (A-7) Alexa Fluor® 680 | sc-514167 AF680 | 200 µg/ml | $350.00 | |||
Antiquitin Antibody (A-7) Alexa Fluor® 790 | sc-514167 AF790 | 200 µg/ml | $350.00 |