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Calpain 1 Antibody (A-5): sc-390677
- Calpain 1 Antibody (A-5) is a mouse monoclonal IgG1 κ, cited in 2 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 682-709 of Calpain 1 catalytic subunit of human origin
- recommended for detection of Calpain 1 catalytic subunit of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, bovine and porcine
- See Calpain 1 (D-11): sc-271313 for Calpain 1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Calpain 1 Antibody (A-5) for WB applications. These reagents are now offered in bundles with Calpain 1 Antibody (A-5) (see ordering information below).
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SEE ALSO...
Calpain 1, also designated µ-calpain, is an intracellular calcium-dependent protease that cleaves cytoskeletal and submembranous proteins. Calpains are nonlysosomal, calcium-activated intracellular cysteine proteases. Calpains mediate specific Ca2+-dependent processes including cell fusion, mitosis and meiosis. Calpains are heterodimers of a small regulatory subunit and one of three large catalytic subunits, designated Calpain 1, Calpain 2 and Calpain p94. Calpastatin regulates Calpain by inhibiting both the proteolytic activity of Calpain and its binding to membranes. Calpastatin exists in two types, tissue type and erythrocyte type, resulting from both alternative splicing and proteolytic processing. Calpain-1 co-localizes with human leukocyte antigen-DR (HLA-DR) on activated microglia in the aging brain. Calpain influences the process of spermatogenesis and the events preceding fertilization, such as the acrosome reaction.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Calpain 1 Antibody (A-5) | sc-390677 | 200 µg/ml | $310.00 | |||
Calpain 1 Antibody (A-5): m-IgG Fc BP-HRP Bundle | sc-540832 | 200 µg Ab; 10 µg BP | $348.00 | |||
Calpain 1 Antibody (A-5): m-IgG1 BP-HRP Bundle | sc-542401 | 200 µg Ab; 20 µg BP | $348.00 | |||
Calpain 1 (A-5) Neutralizing Peptide | sc-390677 P | 100 µg/0.5 ml | $67.00 |