COQ6 Antibody (H-1): sc-393932

COQ6 Antibody (H-1) is an IgG₁ κ mouse monoclonal COQ6 antibody (also designated COQ6 antibody) that detects the COQ6 protein of mouse, rat and human origin by WB, IP, IF and ELISA. COQ6 Antibody (H-1) is available as both the non-conjugated anti-COQ6 antibody form, as well as multiple conjugated forms of anti-COQ6 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor^® conjugates. Coenzyme Q (CoQ), also referred to as ubiquinone, is a fat-soluble component of the electron transport chain that participates in aerobic cellular respiration within mitochondria and is essential for ATP-dependent energy production. CoQ consists of a hydrophobic isoprenoid tail, which anchors it to the membrane, and a quinone head group, which is responsible for the activity of CoQ in the respiratory chain. CoQ biosynthesis requires the formation of a multi-subunit enzyme complex, composed of COQ1 through COQ10, which is highly characterized in yeast. Specifically, COQ6 encodes a flavin-dependent monooxygenase essential for coenzyme Q biosynthesis in yeast. In humans, COQ6 is a 468 amino acid protein whose function is not fully elucidated.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

References:

1. The Saccharomyces cerevisiae COQ6 gene encodes a mitochondrial flavin-dependent monooxygenase required for coenzyme Q biosynthesis.  |  Gin, P., et al. 2003. J Biol Chem. 278: 25308-16. PMID: 12721307
2. A tRNA(TRP) gene mediates the suppression of cbs2-223 previously attributed to ABC1/COQ8.  |  Hsieh, EJ., et al. 2004. Biochem Biophys Res Commun. 317: 648-53. PMID: 15063807
3. Saccharomyces cerevisiae Coq9 polypeptide is a subunit of the mitochondrial coenzyme Q biosynthetic complex.  |  Hsieh, EJ., et al. 2007. Arch Biochem Biophys. 463: 19-26. PMID: 17391640
4. Mitochondrial disorders.  |  Zeviani, M. and Carelli, V. 2007. Curr Opin Neurol. 20: 564-71. PMID: 17885446
5. Coenzyme Q9 provides cardioprotection after converting into coenzyme Q10.  |  Lekli, I., et al. 2008. J Agric Food Chem. 56: 5331-7. PMID: 18543930
6. Biosynthesis and bioproduction of coenzyme Q10 by yeasts and other organisms.  |  Kawamukai, M. 2009. Biotechnol Appl Biochem. 53: 217-26. PMID: 19531029

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-COQ6 Antibody (H-1) has 7 citations in a variety of scientific publications.

Primary antibodies like Anti-COQ6 Antibody (H-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

COQ6 Antibody (H-1) Specifications

Alternate Product Name

COQ6

Product Clone Name

H-1

Classification

Primary Antibody

Clonality

Monoclonal Antibody

Antibody Isotype

IgG₁ kappa light chain

Amino Acids

130-155

Epitope Target

COQ6

Epitope Species

human

Product Reactivity/Detection

COQ6

Species Reactivity/Detection

mouse, rat, human

Additional Mammalian Reactivity

equine, canine, bovine and porcine

Additional Non-Mammalian Reactivity

N/A

Applications

WB, IP, IF, ELISA

Vialing Information

Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations

7 citations in various scientific publications

Recommended Secondary Detection Reagents

Mouse IgG Fc Binding Proteins

• m-IgG Fc BP-HRP: sc-525409 (Mouse IgG Fc binding protein conjugated to horseradish peroxidase)
• m-IgG Fc BP-B: sc-533652 (Mouse IgG Fc binding protein conjugated to biotin)
• m-IgG Fc BP-FITC: sc-533651 (Mouse IgG Fc binding protein conjugated to fluorescein isothiocyanate)
• m-IgG Fc BP-CFL 488: sc-533653 (Mouse IgG Fc binding protein conjugated to CruzFluor™ 488)
• m-IgG Fc BP-CFL 555: sc-533654 (Mouse IgG Fc binding protein conjugated to CruzFluor™ 555)
• m-IgG Fc BP-CFL 594: sc-533655 (Mouse IgG Fc binding protein conjugated to CruzFluor™ 594)
• m-IgG Fc BP-CFL 647: sc-533656 (Mouse IgG Fc binding protein conjugated to CruzFluor™ 647)
• m-IgG Fc BP-CFL 680: sc-533657 (Mouse IgG Fc binding protein conjugated to CruzFluor™ 680)
• m-IgG Fc BP-CFL 790: sc-533658 (Mouse IgG Fc binding protein conjugated to CruzFluor™ 790)

• m-IgG₁ BP-HRP: sc-525408 (Mouse IgG₁ binding protein conjugated to horseradish peroxidase)
• m-IgG₁ BP-B: sc-533660 (Mouse IgG₁ binding protein conjugated to biotin)
• m-IgG₁ BP-FITC: sc-533659 (Mouse IgG₁ binding protein conjugated to fluorescein isothiocyanate)
• m-IgG₁ BP-CFL 488: sc-533661 (Mouse IgG₁ binding protein conjugated to CruzFluor™ 488)
• m-IgG₁ BP-CFL 555: sc-533662 (Mouse IgG₁ binding protein conjugated to CruzFluor™ 555)
• m-IgG₁ BP-CFL 594: sc-533663 (Mouse IgG₁ binding protein conjugated to CruzFluor™ 594)
• m-IgG₁ BP-CFL 647: sc-533664 (Mouse IgG₁ binding protein conjugated to CruzFluor™ 647)
• m-IgG₁ BP-CFL 680: sc-533665 (Mouse IgG₁ binding protein conjugated to CruzFluor™ 680)
• m-IgG₁ BP-CFL 790: sc-533666 (Mouse IgG₁ binding protein conjugated to CruzFluor™ 790)

Available Conjugates/Forms

AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin