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CTH Antibody (D-12): sc-365382
- CTH Antibody (D-12) is a mouse monoclonal IgG1 κ, cited in 11 publications, provided at 200 µg/ml
- raised against amino acids 61-227 mapping within an internal region of CTH of human origin
- recommended for detection of CTH isoforms 1 and 2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- See CTH (F-1): sc-374249 for CTH antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for CTH Antibody (D-12) for WB and IHC(P) applications. These reagents are now offered in bundles with CTH Antibody (D-12) (see ordering information below).
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SEE ALSO...
CTH (cystathionine γ-lyase), also known as CSE or γ-cystathionase, is a member of the trans-sulfuration enzyme family and participates in the trans-sulfuration pathway. CTH is a cytoplasmic enzyme produced in the cytosol and is responsible for catalyzing the pyridoxal phosphate-dependent β-disulfide elimination reaction resulting in ammonium, pyruvate and thiocysteine. The thiocysteine that is produced may then react with other thiols (or cysteine) and form hydrogen sulfide (H2S). Thus, CTH is the major H2S-producing enzyme in kidney, liver, vascular smooth muscle cells and enterocytes. The endogenous production of H2S plays a significant role in the regulation of cellular functions, including cell growth, hyperpolarization of cell membranes, modulation of neuronal excitability and relaxation of smooth muscle cells. Mutations in the gene encoding CTH can result in the autosomal recessive disease cystathioninuria; a disorder characterized by the unusual accumulation of plasma cystathionine causing increased urinary excretion.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CTH Antibody (D-12) | sc-365382 | 200 µg/ml | $310.00 | |||
CTH Antibody (D-12): m-IgG Fc BP-HRP Bundle | sc-540334 | 200 µg Ab; 10 µg BP | $348.00 | |||
CTH Antibody (D-12): m-IgG1 BP-HRP Bundle | sc-542049 | 200 µg Ab; 20 µg BP | $348.00 |