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Delivery of copper to a specific P-type ATPase in the Golgi apparatus (Ccc2 in yeast, ATP7A and ATP7B in humans) is an important step in copper homeostasis that is accomplished by a small copper chaperone protein. HAH1 (also designated ATOX1), a metal transport protein that belongs to the ATX1 family, is involved in cellular antioxidant defense and can bind and deliver cytosolic copper to the copper ATPase proteins. Both HAH1 (the human homolog of Atx1) and Atx1 preferentially interact with domains 2 and 4 of ATP7B. Atx1 also interacts with both Ccc2 domains.
Ordering Information
Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HAH1 Antibody (22-B) | sc-100557 | 100 µg/ml | $327.00 |