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Acyl-CoA dehydrogenase is a family of enzymes that localize to the mitochondrion and target acyl chain lengths of 4 to 16 by use of the mitochondrial fatty acid b-oxidation pathway. In mammalian tissue, many straight-chain acyl-CoA dehydrogenases possess different substrate specificities. In rare cases, irregularities in medium-chain acyl-CoA dehydrogenase can cause fasting hypoglycemia, hepatic dysfunction and encephalopathy, often resulting in death in infancy. MCAD, also designated acyl-CoA dehydrogenase, medium-chain (ACADM) and MCADH, is a homotetramer. The MCAD gene encodes a 421 amino acid protein with characteristics of mitochondrial protein transit peptides. The protein shows 88% sequence identity with MCAD of porcine origin. Medium-chain acyl-CoA dehydrogenase catalyzes the initial reaction in the b-oxidation of C4 to C12 straight-chain acyl-CoAs.
Ordering Information
Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MCAD Antibody (G-4) | sc-365109 | 200 µg/ml | $310.00 | |||
MCAD Antibody (G-4): m-IgG Fc BP-HRP Bundle | sc-540313 | 200 µg Ab; 10 µg BP | $348.00 | |||
MCAD Antibody (G-4): m-IgG1 BP-HRP Bundle | sc-542034 | 200 µg Ab; 20 µg BP | $348.00 | |||
MCAD (G-4) Neutralizing Peptide | sc-365109 P | 100 µg/0.5 ml | $67.00 |