Click on image or enlarge button to enlarge
PLC β4 Antibody (D-7): sc-166133
- PLC β4 Antibody (D-7) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 876-1115 of PLC β4 of human origin
- recommended for detection of PLC β4 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for PLC β4 Antibody (D-7) for WB applications. These reagents are now offered in bundles with PLC β4 Antibody (D-7) (see ordering information below).
Phosphoinositide-specific phospholipase C (PLC) plays a critical role in the initiation of receptor mediated signal transduction through the generation of the two second messengers, inositol 1, 4, 5-triphosphate and diacylglycerol from phosphatidylinositol 4, 5 bisphosphate. A total of eight mammalian PLC isozymes have been described (PLC β1, PLC β2, PLC β3, PLC β4, PLC γ1, PLC γ2, PLC δ1 and PLC δ2). The γ-type enzymes are unique in that they contain SH2 and SH3 domains. Moreover, the two γ-type enzymes, but not the β and δ isozymes, are subject to activation by a number of protein tyrosine kinases which associate with their SH2 domains and induce their activation by phosphoryation. In contrast, activation of PLC β1, PLC β2 and PLC β3 is mediated by the a subunits of the Gq class of heterotrimeric G proteins and by certain bg G protein subunits. The regulatory mechanisms for PLC δ1 and PLC δ2 are not yet resolved.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PLC β4 Antibody (D-7) | sc-166133 | 200 µg/ml | $310.00 | |||
PLC β4 Antibody (D-7): m-IgG Fc BP-HRP Bundle | sc-540022 | 200 µg Ab; 10 µg BP | $348.00 | |||
PLC β4 Antibody (D-7): m-IgG1 BP-HRP Bundle | sc-541850 | 200 µg Ab; 20 µg BP | $348.00 |