Aquaporin 8/AQP8 Antibody (14-Z): sc-81870

AQP8 Antibody (14-Z) is an IgG_2a κ mouse monoclonal AQP8 antibody (also designated aquaporin 8 antibody) that detects the AQP8 protein of mouse, rat and human origin by WB, IP and ELISA. AQP8 Antibody (14-Z) is available as the non-conjugated anti-AQP8 antibody. Human AQP8 (Aquaporin 8) is a 261 amino acid protein that contains 6 membrane-spanning domains, 2 conserved asn-pro-ala (NPA) motifs, which are characteristic of MIP (major intrinsic protein) family members, and 3 N-linked glycosylation sites. Aquaporins (AQPs) are a large family of integral membrane water transport channel proteins that facilitate the transport of water through the cell membrane. This function is conserved in animals, plants and bacteria. Many isoforms of aquaporin have been identified in mammals, designated AQP0 through AQP10. Aquaporins are widely distributed and it is not uncommon for more than one type of AQP to be present in the same cell. Although most aquaporins are only permeable to water, AQP3, AQP7, AQP9 and one of the two AQP10 transcripts are also permeable to urea and glycerol. Aquaporins are involved in renal water absorption, generation of pulmonary secretions, lacrimation, and the secretion and reabsorption of cerebrospinal fluid and aqueous humor.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

References:

1. The mammalian aquaporin water channel family: A promising new drug target.  |  Beitz, E. and Schultz, JE. 1999. Curr Med Chem. 6: 457-67. PMID: 10213793
2. Assignment of the aquaporin-8 water channel gene (AQP8) to human chromosome 16p12.  |  Viggiano, L., et al. 1999. Cytogenet Cell Genet. 84: 208-10. PMID: 10393433
3. cDNA cloning and gene structure of a novel water channel expressed exclusively in human kidney: evidence for a gene cluster of aquaporins at chromosome locus 12q13.  |  Ma, T., et al. 1996. Genomics. 35: 543-50. PMID: 8812490
4. Cloning and functional expression of human aquaporin8 cDNA and analysis of its gene.  |  Koyama, N., et al. 1998. Genomics. 54: 169-72. PMID: 9806845
5. Aquaporins.  |  Echevarría, M. and Ilundáin, AA. 1998. J Physiol Biochem. 54: 107-18. PMID: 9858131

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Aquaporin 8/AQP8 Antibody (14-Z) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-Aquaporin 8/AQP8 Antibody (14-Z) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Aquaporin 8/AQP8 Antibody (14-Z) Specifications

Alternate Product Name

aquaporin 8

Product Clone Name

14-Z

Classification

Primary Antibody

Clonality

Monoclonal Antibody

Antibody Isotype

IgG_2a kappa light chain

Amino Acids

1-256

Epitope Target

AQP8

Epitope Species

human

Product Reactivity/Detection

AQP8

Species Reactivity/Detection

mouse, rat, human

Additional Mammalian Reactivity

N/A

Additional Non-Mammalian Reactivity

N/A

Applications

WB, IP, ELISA

Vialing Information

Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations

5 citations in various scientific publications

Recommended Secondary Detection Reagents

N/A

Available Conjugates/Forms

N/A