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ATP6E, also known as V-ATPase E, is a vacuolar-type H+-ATPase (V-ATPase). V-ATPase is a multisubunit enzyme responsible for acidification of eukaryotic intracellular organelles. V-ATPases pump protons against an electrochemical gradient, while F-ATPases reverse the process, thereby synthesizing ATP. A peripheral V1 domain, which is responsible for ATP hydrolysis, and an integral V0 domain, which is responsible for proton translocation, compose V-ATPase. Nine subunits (A-H) make up the V1 domain and five subunits (a, d, c, c′ and c") make up the V0 domain. Like F-ATPase, V-ATPase most likely operates through a rotary mechanism. ATP6E controls acidification of the vacuolar system and provides the main proton-motive force.
Ordering Information
Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ATP6E Antibody (C-1) | sc-48375 | 200 µg/ml | $310.00 | |||
ATP6E Antibody (C-1): m-IgG Fc BP-HRP Bundle | sc-536820 | 200 µg Ab; 10 µg BP | $348.00 | |||
ATP6E Antibody (C-1): m-IgGκ BP-HRP Bundle | sc-533987 | 200 µg Ab; 40 µg BP | $348.00 | |||
ATP6E Antibody (C-1): m-IgG1 BP-HRP Bundle | sc-544840 | 200 µg Ab; 20 µg BP | $348.00 |