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The ubiquitously expressed sodium/potassium-ATPase (Na+/K+-ATPase) exists as a oligomeric plasma membrane complex that couples the hydrolysis of one molecule of ATP to the importation of three Na+ ions and two K+ ions against their respective electrochemical gradients. As a member of the P-type family of ion motives, Na+/K+-ATPase plays a critical role in maintaining cellular volume, resting membrane potential and Na+-coupled solute transport. Multiple isoforms of three subunits, α, β and γ, comprise the Na+/K+-ATPase oligomer. The α subunit contains the binding sites for ATP and the cations; the glycosylated β subunit ensures correct folding and membrane insertion of the α subunits. The small γ subunit co-localizes with the α subunit in nephron segments, where it increases the affinity of Na+/K+-ATPase for ATP. The β subunit, but not the γ subunit, is essential for normal activity of Na+/K+-ATPase.
Ordering Information
Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
beta 1 Sodium Potassium ATPase/ATP1B1 Antibody (M17-P5-F11) | sc-58627 | 200 µg/ml | $310.00 | |||
beta 1 Sodium Potassium ATPase/ATP1B1 Antibody (M17-P5-F11): m-IgG Fc BP-HRP Bundle | sc-537153 | 200 µg Ab; 10 µg BP | $348.00 | |||
beta 1 Sodium Potassium ATPase/ATP1B1 Antibody (M17-P5-F11): m-IgGκ BP-HRP Bundle | sc-534348 | 200 µg Ab; 40 µg BP | $348.00 | |||
beta 1 Sodium Potassium ATPase/ATP1B1 Antibody (M17-P5-F11): m-IgG2a BP-HRP Bundle | sc-547935 | 200 µg Ab; 10 µg BP | $348.00 |