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B7-2 Antibody (B-T7): sc-58915
- B7-2 Antibody (B-T7) is a mouse monoclonal IgG1 provided at 100 µg/ml
- raised against B7-2 of human origin
- recommended for detection of B7-2 of human origin by WB, IP and FCM
- See B7-2 (D-6): sc-28347 for B7-2 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for B7-2 Antibody (B-T7). This work is in progress.
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T cell proliferation and lymphokine production are triggered by occupation of the TCR by antigen, followed by a costimulatory signal that is delivered by a ligand expressed on antigen presenting cells. The B7-related cell surface proteins B7-1 (CD80) and B7-2 (CD86) expressed on antigen presenting cells bind the homologous T cell receptors CD28 and CTLA-4 (cytotoxic T lymphocyte-associated protein-4) and trigger costimulatory signals for optimal T cell activation. CTLA-4 shares 31% overall amino acid identity with CD28, and it has been proposed that CD28 and CTLA-4 are functionally redundant. SLAM is a novel receptor on T cells that, when engaged, potentiates T cell expansion in a CD28-independent manner. B7, also designated BB1, is another ligand or counterreceptor for CD28 and CTLA-4 that is expressed on the antigen-presenting cell.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
B7-2 Antibody (B-T7) | sc-58915 | 100 µg/ml | $310.00 |