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The CD1 multigene family encodes five forms of the CD1 T cell surface glycoprotein in human, designated CD1A, 1B, 1C, 1D and 1E. CD1, a type 1 membrane protein, has structural similarity to the MHC class I antigen and has been shown to present lipid antigens for recognition by T lymphocytes. CD1 antigens are associated with β-2-Microglobulin and expressed on cortical thymocytes, Langerhans cells, a B cell subset and some dendritic cells. Adaptor protein complexes and CD1-associated chaperones control CD1 trafficking and the development and activation of CD1-restricted T cells. CD1D is present on human intestinal epithelial cells (IEC) and exists as a β-2-Microglobulin-independent nonglycosylated form or a β-2-Microglobulin-dependent glycosylated form. The human CD1D gene maps to chromosome 1q23.1 and encodes a 335 amino acid protein that influences normal T cell maturation.
Ordering Information
Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD1D Antibody (3H649) | sc-70571 | 200 µg/ml | $310.00 | |||
CD1D Antibody (3H649): m-IgG Fc BP-HRP Bundle | sc-539295 | 200 µg Ab; 10 µg BP | $348.00 | |||
CD1D Antibody (3H649): m-IgG1 BP-HRP Bundle | sc-541387 | 200 µg Ab; 20 µg BP | $348.00 |